Evaluation of drug utilization pattern, quality of life and pharmaco-economics in patients of contact dermatitis: a prospective observational study
DOI:
https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20214910Keywords:
Contact dermatitis, Drug utilization pattern, Pharmacoeconomics, Quality of lifeAbstract
Background: Contact dermatitis (CD) is a common inflammatory skin condition due to T-cell mediated immune reaction on exposure to different allergens. The disease significantly affects Quality of Life (QoL) and all over impact can be seen in Pharmacoeconomics.
Methods: This is the prospective observational study done between October 2019 to February 2020 at Dermatology outpatient department (OPD) of a tertiary care teaching hospital. Patients diagnosed with CD aged eighteen years or older of either gender and willing to give written consent were included in study. The impact of CD on the QoL of affected persons was assessed using the Dermatology Life Quality Index (DLQI). Direct, indirect and total cost as well as percentage variation in cost of individual drugs was calculated for Pharmacoeconomics analysis.
Results: The study population consisted of 180 patients. The most commonly prescribed drugs were corticosteroids (47.44%). The average score of DLQI at baseline was 8.97±4.85. The DLQI score was significantly more impaired in women as compared to men (12.91versus 4.93) (p=0.0001). Average income per month was 11,611.11±230.34₹. The average direct, indirect and total cost was 131.55±70.55 ₹, 136.44±16.93 ₹ and 168.11±74.08₹ respectively. The percentage variation of cost was largest for prednisolone 5 mg tablet and least for clobetasol cream (0.05%).
Conclusions: The impact of CD on QoL and Pharmacoeconomic burden is significant and requires specific attention in health care facilities.
References
Romita P, Foti C, Calogiuri G, Cantore S, Ballini A, Dipalma G et al. Contact dermatitis due to transdermal therapeutic systems: a clinical update. Acta Biomed. 2018;90(1):5-10.
Peiser M, Tralau T, Heidler J. Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Current knowledge assembled at an international workshop at BfR, Germany. Cell Mol Life Sci. 2012;69(5):763-81.
Patel V, Vaidya R, Naik D, Borker P. Irrational drug use in India: A prescription survey from Goa. J Postgrad Med. 2005;51(1):9-12.
Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI)—a simple practical measure for routine clinical use. Clinical and Experimental Dermatology. 1994;19(3):210-6.
Hongbo Y, Thomas CL, Harrison MA, Salek MS, Finlay AY. Translating the science of quality of life into practice: What do dermatology life quality index scores mean? Journal of Investigative Dermatology. 2005;125(4):659-64.
Aravind SR, Rao AC, Andrade C, Shetty DP, Geethamani V, Divaker H, et al. Current Index of Medical Specialties. UBM Medica India. 2017;382-400.
Aravind SR, Rao AC, Andrade C, Shetty DP, Geethamani V, Divaker H et al. Indian Drug Review, Drug Triple Compedium. UBM Medica India. 2017;23(3):248-57.
Jadhav NB, Bhosale MS, Adhav CV. Cost Analysis Study of Oral Antidiabetic Drugs Available In Indian Market. Int J Med Res Health Sci. 2013;2(1):63-9.
Mancini AJ, Kaulback K, Chamlin SL. The socioeconomic impact of atopic dermatitis in the United States: a systematic review. Pediatr Dermatol. 2008;25(1):1-6.
Red book. Montvale (NJ): Medical Economics. 2004.
Bylappa BK, Patil RT, Pillai RT. Drug prescribing pattern of topical corticosteroids in dermatology unit of a tertiary-care hospital. Int J Med Sci Public Health. 2015;4(12):1702-7.
Diepgen TL, Weisshaar E. Contact dermatitis: epidemiology and frequent sensitizers to cosmetics. J Eur Acad Dermatol Venereol. 2007;21(2):9-13.
Kirubakaran JJ, Khandavilli SK, Manasa S, Satyanarayana AN, Srilakshmi KV, Palivela H et al. Evaluation and Management of Atopic Dermatitis, Ind J Pharmacy Practice. 2020;13(2):145-50.
Richard P, Riojas M. Diagnosis and management of Contact Dermatitis, Texas Am Fam Physician. 2010;82(3):249-55.
Divyashanthi CM, Bhanu P, Pandiamunian J. WHO core prescribing indicators in patients with allergic contact dermatitis in a coastal town of South India. Int J Basic Clin Pharmacol. 2017;6(1):61-6.
Pathak AK. Drug Utilization Pattern for Skin Diseases in a Indian Tertiary Care Hospital - A Prescription Survey. Journal of Clinical and Diagnostic Research. 2016;10(2):FC01-5.
Kalboussi H. Impact of Allergic Contact Dermatitis on the Quality of Life and Work Productivity. Dermatology Research and Practice. 2019;2019:3797536.
