Evaluation of serum 25-hydroxy vitamin D levels in alopecia areata of scalp: a cross sectional observational study
DOI:
https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20214200Keywords:
Alopecia areata, 25-hydroxy vitamin D, SALT scoreAbstract
Background: Alopecia areata (AA) is a T cell-mediated autoimmune disorder of anagen hair follicle leading to distressing and relapsing non-scarring hair loss. Vitamin D an immunomodulator plays important role in regulating normal hair cycle. Recent evidence suggests inconsistent association between vitamin D deficiency and alopecia areata.
Methods: Hospital-based cross-sectional observational study of forty untreated cases of alopecia areata and forty age and sex-matched healthy controls in 18-45 years of age group recruited from out-patient department. Each patient will undergo a detailed history, clinical examination and SALT (Severity of alopecia tool) scoring. Enhanced chemiluminesence method (Eci) will be used to estimate serum 25-hydroxy vitamin D [25(OH)D].
Results: The mean 25(OH)D level in patients of AA was 12.45±4.80 ng/ml (deficient), while that of controls was 33.73±10.02ng/ml (normal). The difference between the levels of 25(OH)D in patients of AA and controls came out to be statistically significant (p≤0.0001). A strong negative correlation was seen between SALT score and 25(OH)D level (-0.32), which was found to be statistically significant (p=0.0462).
Conclusions: The present study established that vitamin D levels are either insufficient/deficient in alopecia areata and it correlates negatively with severity of SALT (severity of alopecia tool) score.
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References
Thomas EA, Kadyan RS. Alopecia areata and autoimmunity: a clinical study. Indian J Dermatol. 2008;53(2):70-4.
Berker DAR, Messenger AG, Sinclair RD. Disorders of hair. In: Burns DA, Breathnach SM, Cox N, Griffith CE, eds. Rooks textbook of dermatology. Oxford: Wiley-Blackwell; 2004: 63.1-63.120.
Tobin DJ, Orientreich N, Fenton DA, Bystryn JC. Antibodies to hair follicles in alopecia areata. J Invest Dermatol. 1994;11:721-4.
Cerman A, Sarikaya Solak S, Kivanc Altunay I. Vitamin D deficiency in alopecia areata. Br J Dermatol. 2014;170(6):1299-304.
Arnson Y, Amital H, Shoenfeld Y. Vitamin D and autoimmunity: new aetiological and therapeutic consideration. Ann Rheum Dis. 2007;66:1137-42.
Boucher BJ. Curcumin and diabetes: a role of the vitamin D receptor? Br J Nutr. 2012;108:2104.
Mahamid M, Elhija O, Samamra M, Mahamid A, Nseir W. Association between vitamin D levels and alopecia areata. Isr Med Assoc J. 2014;16:367-70.
Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L. Vitamin D3: A helpful immune-modulator. Immunology 2011;134:123-39.
Olsen E, Hordinsky M, Hull S, Price V, Roberts J, Shapiro J, et al. Alopecia areata investigational assessment guidelines. National Alopecia Areata Foundation. J Am Acad Dermatol.1999;40:242-6.
Gupta A. Vitamin D deficiency in India: prevalence, causalities and interventions. Nutrients. 2014;6(2):729-75.
Akar A, Orkunoglo FE, Ozata M, Sengul A, Gur AR. Lack of association between vitamin D receptor Fokl polymorphism and alopecia areata. Eur J Dermatol. 2004;14:156-8.
Akar A, Orkunoglo FE, Tunca M, Tastan HB, Kurumlu Z. Vitamin D receptor gene polymorphisms are not associated with alopecia areata. Int J Dermatol. 2007;46:927-9.
Athanassiou I, Athanassiou P, Lyrak A, Raftakis I, Antoniadis C. Vitamin D and rheumatoid arthritis. Ther Adv Endocrinol Metab. 2012;3:181-7.
Saleh HM, Abdel FNS, Hamza HT. Evaluation of serum 25-hydroxyvitamin D levels in vitiligo patients with and without autoimmune diseases. Photodermatol Photoimmunol Photomed. 2013;29(1):34-40.
Bakry OA, Farargy SM, Shafiee MK, Soliman A. Serum Vitamin D in patients with alopecia areata. Indian Dermatol Online J. 2016;7(5):371-7.
Yilmaz N, Serarslan G, Gokce C. Vitamin D concentrations are decreased in patients with alopecia areata. Vitam Trace Elem. 2012;1:105-9.
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