Evaluation of serum 25-hydroxy vitamin D levels in alopecia areata of scalp: a cross sectional observational study


  • Manish Jain Department of Skin and VD, GMC, Kota, Rajasthan, India
  • Devendra Kumar Yadav Department of Skin and VD, GMC, Kota, Rajasthan, India
  • Asha Nyati Department of Skin and VD, GMC, Kota, Rajasthan, India
  • Mohan Lal Department of Skin and VD, GMC, Kota, Rajasthan, India




Alopecia areata, 25-hydroxy vitamin D, SALT score


Background: Alopecia areata (AA) is a T cell-mediated autoimmune disorder of anagen hair follicle leading to distressing and relapsing non-scarring hair loss. Vitamin D an immunomodulator plays important role in regulating normal hair cycle. Recent evidence suggests inconsistent association between vitamin D deficiency and alopecia areata.

Methods: Hospital-based cross-sectional observational study of forty untreated cases of alopecia areata and forty age and sex-matched healthy controls in 18-45 years of age group recruited from out-patient department. Each patient will undergo a detailed history, clinical examination and SALT (Severity of alopecia tool) scoring. Enhanced chemiluminesence method (Eci) will be used to estimate serum 25-hydroxy vitamin D [25(OH)D].

Results: The mean 25(OH)D level in patients of AA was 12.45±4.80 ng/ml (deficient), while that of controls was 33.73±10.02ng/ml (normal). The difference between the levels of 25(OH)D in patients of AA and controls came out to be statistically significant (p≤0.0001). A strong negative correlation was seen between SALT score and 25(OH)D level (-0.32), which was found to be statistically significant (p=0.0462).

Conclusions: The present study established that vitamin D levels are either insufficient/deficient in alopecia areata and it correlates negatively with severity of SALT (severity of alopecia tool) score.

Author Biographies

Manish Jain, Department of Skin and VD, GMC, Kota, Rajasthan, India


Devendra Kumar Yadav, Department of Skin and VD, GMC, Kota, Rajasthan, India


Asha Nyati, Department of Skin and VD, GMC, Kota, Rajasthan, India


Mohan Lal, Department of Skin and VD, GMC, Kota, Rajasthan, India



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Original Research Articles