Profile of mean platelet volume, neutrophil - lymphocyte ratio and platelet - lymphocyte ratio in patient with psoriasis
Keywords:Psoriasis, MVP, PLR, Severity, NLR, PASI
Background: Psoriasis is a chronic, inflammatory, systemic disease. In response to therapy in psoriasis patients, the psoriasis area severity index (PASI) is used to evaluate the disease activity. However more objective laboratory tools should be developed besides PASI. In various inflammatory diseases, mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), and platelet lymphocyte ratio (PLR) are inflammatory biomarkers that are known to be evaluated. The aim of the study was to assess the frequency of platelet activation and leukocyte infiltration by measuring MPV, NLR, and PLR.
Methods: This was a case-control observational study conducted at department of dermatology and venereology at Bangabandhu Sheikh Mujib Medical University from July 2016 to December 2017. A total of 55 psoriasis cases and 55 healthy controls were included according to inclusion and exclusion criteria.
Results: We have investigated a total of 55 psoriasis patients and another 55 age-sex matched control. There were 31 males (56.36%) and 24 females (43.44%) psoriasis patients in the study. The mean age of the patient was 34.27±13.44 years. Mean±standard deviation (SD) value of MPV, NLR, and PLR in our study cases were 9.92±1.21, 4.32±8.53, and 292.96±88.80 whereas in the case of control values were 9.46±0.636, 4.54±8.51, and 162.26±103.38 respectively.
Conclusions: In conclusion, we suggest MPV is a strong indicator of psoriasis severity. MPV and PLR should be followed up routinely to take preventive measures against psoriasis-related micro and macro vascular thrombotic complications.
Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis, J Clin Investig. 2005;115:3378-84.
Vanizor Kural B, Orem, Cimsit G. Evaluation of the atherogenic tendency of lipid and lipoprotein content and their relationship with oxidant-anti oxidant system in patients with psoriasis. Clin Chem Acta. 2003;328:71-82.
Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. C-reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapy. J Eur Acad Dermatol Venereol. 2010;24(7):789-96.
Kasperska-Zajac A, Nowakowski M, Rogala B. Enhanced platelet activation in patients with atopic eczema/dermatitis syndrome. Inflammation. 2004;28:299-302.
Karabudak O, Ulusoy RE, Erikci AA, Solmazgul E, Dogan B. Inflammation and hypercoagulable state in adult psoriatic men. Acta Derm Venereol. 2008;88:337-40.
Hundelshausen V, Weber P. Platelets as Immune Cells: Bridging Inflammation and Cardiovascular Disease. Circulation Res. 2007;100(1):27-40.
Şenel E, Acar B, Demir E. Mean Platelet Volume: A Reliable Marker of Inflammation in Recurrent Apthous Stomatitis and Behçet Disease? Indian Dermatol Online J. 2017;8(6):468-70.
Pauling JD, O'Donnell VB, Mchugh NJ. The contribution of platelets to the pathogenesis of Raynaud's phenomenon and systemic sclerosis. Platelets. 2013;24:503-15.
Yilmaz MB, Cihan G, Guray Y. Role of mean platelet volume in triagging acute coronary syndromes. J Thromb Thrombolysis. 2008;26:49-54.
Uslu AU, Küçük A, Şahin A, Ugan Y, Yılmaz R, Güngör T, Bağcacı S, Küçükşen S. Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. Int J Rheum Dis. 2015;18(7):731-5.
Çerman A, Karabay E, Altunay İ. Evaluation of neutrophil-lymphocyte ratio and mean platelet volume in patients with psoriasis. Med Bull Sisli Etfal Hosp. 2016;50(2):137-41.
Yurtdaş M, Yaylali YT, Kaya Y, Ozdemir M, Ozkan I, Aladağ N. Neutrophil-to-lymphocyte ratio may predict subclinical atherosclerosis in patients with psoriasis. Echocardiography. 2014;31(9):1095-104.
Nikolsky E, Grines CL, Cox DA, Garcia E, Tcheng JE, Sadeghi M. Impact of baseline platelet count in patients undergoing primary percutaneous coronary intervention in acute myocardial infarction (from the CADILLAC trial). Am J Cardiol. 2007;99:1055-61.
Balta S, Ozturk C. The platelet-lymphocyte ratio: A simple, inexpensive and rapid prognostic marker for cardiovascular events. Platelets. 2015;26(7):680-1.
Toprak E, Bozkurt M, Dinçgez Çakmak B, Özçimen E, Silahlı M, Ender Yumru A, Çalışkan E. Platelet to Lymphocyte Ratio: A New Inflammatory Marker For Diagnosis of Preterm Premature Rupture of Membranes. J Turkish-German Gynecol Assoc. 2017;32(2):31-4.
Canpolat F, Akpinar H, Eskioğlu F. Mean platelet volume in psoriasis and psoriatic arthritis. Clin Rheumatol. 2010;29:325-8.
Kılic S, Reşorlu H, Işık S, Oymak S, Akbal A, Hiz M, Öğretmen Z. Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis. Adv Dermatol Allergol. 2017;2:126-30.
Chandrasekar T, Yang JC, Gao AC, Evans CP. Mechanisms of resistance in castration-resistant prostate cancer (CRPC). Transl Androl Urol. 2015;4(3):365-80.
Kim D, Lee J, Kim S, Lee M. Mean Platelet Volume Is Elevated in Patients with Psoriasis Vulgaris. Yonsei Med J. 2015;56(3):712.
Asahina Y, Nomura M, Ohsuga K. Astrophysical J. 2017;840(25):9.
Ahmad Z, Akhtar S, Maan M, Khalid U, Hussain A. Comparison of mean platelet volume in patients with psoriasis and healthy individuals. J Pak Assoc Dermatol. 2014;24(1):1-3.
Kim D, Kim J, Hur JK, Been KW, Yoon SH, Kim JS. Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells. Nat Biotechnol. 2016;34(8):863-8.
Karabudak O, Ulusoy RE, Erikci AA, Solmazgul E, Dogan B, Harmanyeri Y. Inflammation and hypercoagulable state in adult psoriatic men. Acta Derm Venereol. 2008;88(4):337-40.
Saleh H, Attia E, Onsy A, Saad A, Abd Ellah M. Platelet activation: a link between psoriasisper seand subclinical atherosclerosis - a case-control study. Br J Dermatol. 2013;169(1):68-75.
Polat G, Ugan RA, Cadirci E, Halici Z. Sepsis and Septic Shock: Current Treatment Strategies and New Approaches. Eurasian J Med. 2017;49:53-8.
Ahmed S, Yousaf M, Mothana RA, Al-Rehaily AJ. Studies on wound healing activity of some euphorbia species on experimental rats. Afr J Tradit Complement Altern Med. 2016;13(5):145-52.