Metabolic syndrome in alopecia areata: an observational study at a tertiary care center


  • Subrata Kumar Das Department of Dermatology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India
  • Saptadipa Das Department of Medicine, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India



Alopecia areata, Metabolic syndrome, Low-density lipoprotein


Background: The aim was to evaluate the parameters of metabolic syndrome (MS) in patients of alopecia areata and to investigate the possibility of an existing relationship between MS and alopecia areata (AA).

Methods: This cross-sectional observational study included 50 patients with AA who attended OPD of department of dermatology at a tertiary care center during a period of 1 year. Clinical and laboratory parameters were noted in each patient.

Results: This study included 50 patients with AA (33 males and 17 females). In the present study maximum number of patients belonged to the age group 20-30 years with 23 patients, followed by 30-40 years with 17  patients. Most of the study subjects, 17 were college students and number of employees were 15. Out of 50 patients 44  had patch(es) and 2 patient had alopecia totalis. In this study out of 50 patients, 38 had mild AA, 7 had AA and 5 patients had severe AA. No significant derangement of clinical and laboratory parameters of MS observed in patients of AA.

Conclusions: In the present study we did not observe any significant derangement of clinical and laboratory parameters of  MS  in patients of alopecia areata.

Author Biography

Subrata Kumar Das, Department of Dermatology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India

Senior Resident Doctor , Department of Dermatology, SMIMS, Sikkim


Bolduc C. Alopecia areata. Dermatol. 2006:1-33.

Safavi KH, Muller SA, Suman VJ, Moshell AN, Melton LJ. 3rd Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc. 1995;70(7):628-33.

Yang S, Yang J, Liu JB, Wang HY, Yang Q, Gao M, et al. The genetic epidemiology of alopecia areata in China. Br J Dermatol. 2004;151(1):16-23.

Dogra D, Sood A, Khaitan BK. Alopecia areata in identical twins. Indian J Dermatol Venereol Leprol. 1996;62(3):199.

Friedmann PS. Alopecia areata and auto-immunity. Br J Dermatol. 1981;105(2):153-7.

Gilhar A, Kalish RS. Alopecia areata: a tissue specific autoimmune disease of the hair follicle. Autoimmun Rev. 2006;5(1):64-9.

Friedmann PS. Decreased lymphocyte reactivity and autoimmunity in alopecia areata. Br J Dermatol. 1981;105(2):145-51.

Madani S, Shapiro J. Alopecia areata update. J Am Acad Dermatol. 2000;42(4):549-66.

Hordinsky MK, Hallgren H, Nelson D, Filipovich AH. Suppressor cell number and function in alopecia areata. Arch Dermatol. 1984;120(2):188-94.

Puavilai S, Puavilai G, Charuwichitratana S, Sakuntabhai A, Sriprachya-Anunt S. Prevalence of thyroid diseases in patients with alopecia areata. Int J Dermatol. 1994;33(9):632-3.

Lewinski A, Broniarczyk-Dyla G, Sewerynek E, Zerek-Melen G, Szkudlinski M. Abnormalities in structure and function of the thyroid gland in patients with alopecia areata. J Am Acad Dermatol. 1990;23:768-9.

Thomas EA, Kadyan RS. Alopecia areata and autoimmunity: a clinical study. Indian J Dermatol. 2008;53(2):70-4.

Sharma VK, Sialy R, Kumar B, Gupta S. Evaluation of thyroid function in North Indians with alopecia areata: response to intravenous injection of 100 micrograms thyrotropin releasing hormone (TRH). J Dermatol. 1999;26(6):339-42.

Jabbari A, Cerise JE, Chen JC, Mackay-Wiggan J, Duvic M, Price V, et al. Molecular signatures define alopecia areata subtypes and transcriptional biomarkers EBioMedicine. 2016;7:240-7.

Davies JT, Delfino SF, Feinberg CE, Johnson MF, Nappi VL, Olinger JT, et al. Current and emerging uses of statins in clinical therapeutics: a review. Lipid Insights. 2016;9:13-29.

Lim CP, Severin RK, Petukhova L. Big data reveal insights into alopecia areata comorbidities. J Investig Dermatol Symp Proc. 2018;19(1):57-61.

Brunzell JD, Ayyobi AF. Dyslipidemia in the metabolic syndrome and type 2 diabetes mellitus. Am J Med. 2003;115(8):24-8.

Fattah NSA, Ebrahim AA, ElOkda ES. Lipid peroxidation/antioxidant activity in patients with alopecia areata. J Eur Acad Dermatol Venereol. 2011;25(4):403-8.

Wadhwa SL, Khopkar U, Nischal KC. Hair and scalp disorders. In: Valia RG, Valia RA, eds. IADVL Textbook of Dermatology. 3rd ed. Mumbai: Bhalani Publishing House; 2008: 887-9.

Acibucu F, Kayatas M, Candan F. The association of insulin resistance and metabolic syndrome in early androgenetic alopecia. Singapore Med J. 2010;51(12):931-6.

Ahmed I, Nasreen S, Jaehangir U, Wahid Z. Clinical spectrum of alopecia areata and its association with thyroid dysfunction. J Pak Assoc Dermatol. 2012;22(3):207-12.

Messenger AG, Bleehen SS. Expression of HLA-DR by anagen hair follicles in alopecia areata. J Invest Dermatol. 1985;85(6):569-72.

McDonagh AJ, Tazi-Ahnini R. Epidemiology and genetics of alopecia areata. Clin Exp Dermatol. 2002;27(5):405-9.

Tobin DJ, Orentreich N, Fenton DA , Bystryn JC. Antibodies to hair follicles in alopecia areata. J Invest Dermatol. 1994;102(5):721-4.

Baker GH. Psychological factors and immunity. J Psychosom Res. 1987;31(1):1-10.

Price VH. Alopecia areata: Clinical aspects. J Invest Dermatol. 1991;96(5):68.

Muller SA, Winkelmann RK. Alopecia areata. An evaluation of 736 patients. Arch Dermatol. 1963;88:290-7.

Tan E, Tay YK, Goh CL, Chin Giam Y. The pattern and profile of alopecia areata in Singapore-a study of 219 Asians. Int J Dermatol. 2002;41(11):748-53.

Sharma VK, Dawn G, Kumar B. Profile of alopecia areata in Northern India. Int J Dermatol. 1996;35(1):22-7.

Manzoor S, Masood C. Aeopecia areata in Kashmir: a study of 200 patients. Indian J Dermatol Venereol Leprol. 2001;67(6):324-5.

Chu SY, Chen YJ, Tseng WC, Lin MW, Chen TJ, Hwang CY, et al. Comorbidity profiles among patients with alopecia areata: the importance of onset age, a nationwide population-based study. J Am Acad Dermatol. 2011;65(5):949-56.

Ishak RS, Piliang MP. Association between alopecia areata, psoriasis vulgaris, thyroid disease and metabolic syndrome. J Investig Dermatol Symp Proc. 2013;16(1):56-7.

Piva SJ, Duarte MM, DaCruz IB, Coelho AC, Moreira AP, Tonello R, et al. Ischemia-modified albumin as an oxidative stress biomarker in obesity. Clin Biochem. 2011;44(4):345-7.






Original Research Articles