DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20212550

Syphilis on the rise-a retrospective study at a tertiary care hospital in Northeast India

Nandakishore Thokchom, Bharath Meka, Linda Kongbam, Mrudula S., Erika Salam, Tana Ananto, Deepa Yumnam, Bhavya Valsalan

Abstract


Background: Syphilis is an important sexually transmitted disease known for quite a long time. Its recognition and efficient treatment have become all the more necessary in the era of HIV epidemic in many clinical situations.

Methods: A retrospective observational study of 7 years (January 2013 to December 2019) in 43 patients of confirmed syphilis attending regional institute of medical sciences (RIMS), Imphal.

Results: During 7-year study period a sharp rise in syphilis cases were present from 2018 till the end of the study. Out of 43 patients, 39 were males. The most common age group was 25-40 years. Half of them were married. Maximum were heterosexuals and only 8 were homosexuals. Premarital and extra marital exposures were seen in 18 and 3 patients respectively. Patients presented in different forms-primary (48.6%), latent (25.7%) and secondary syphilis (22.8%). No cases of congenital syphilis and neurosyphilis were seen. VDRL titres ranged from 1:4 to 1:32. Six patients had HIV co-infection. No atypical presentations were seen.

Conclusions: Increasing cases of syphilis have been observed in recent years. Syphilis screening and prompt treatment amongst risk groups have become crucial along with proper surveillance and public health measures to prevent disease transmission.


Keywords


Syphilis, Latent, Sexually transmitted infections, Venereal disease research laboratory, Treponema pallidum haemagglutination test, Men who have sex with men

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References


Thappa DM, Kaimal S. Sexually transmitted infections in India: Current status (except human immunodeficiency virus/acquired immunodeficiency syndrome). Indian J Dermatol. 2007;52(2):78.

Peeling RW, Mabey D, Kamb ML, Chen XS, Radolf JD, Benzaken AS. Syphilis. Nat Rev Dis Primers. 2017;3:17073.

Ghanem KG, Ram S, Rice PA. The modern epidemic of syphilis. N Engl J Med. 2020;382(9):845-54.

Newman L, Rowley J, Vander Hoorn S, Wijesooriya NS, Unemo M, Low N et al. Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting. PLoS One. 2015;10:e0143304.

Haldar P, Morineau G, Das A, Mehendale S. A surveillance model for sexually transmitted infections in India. Indian J Public Health. 2015;59:286-94.

National AIDS Control Organization, Ministry of Health and Family Welfare, Government of India. Annual Report. 2016-17.

National AIDS Control Organization, Ministry of Health and Family Welfare, Government of India. Annual Report. 2014-15.

Zamzachin G, Singh NB, Devi TB. STD trends in regional institute of medical sciences, Manipur. Indian J Dermatol Venereol Leprol. 2003;69:151-3.

Ray K, Bala M, Gupta SM, Khunger N, Puri P, Muralidhar S et al. Changing trends in sexually transmitted disease in a regional STD centre in north India. Indian J Med Res. 2006;124:559-68.

Schumacher CM, Ellen J, Rompalo AM. Changes in demographics and risk behaviors of person with early syphilis depending on epidemic phase. Sex Transm Dis. 2008;35:190-6.

Tsai HC, Sy CL, Lee SS, Wann SR, Chen YS. Optimal treatment for asymptomatic neurosyphilis. Int J STD AIDS. 2012;23(10):756-7.

Ross MW, Nyoni J, Ahaneku HO, Mbwambo J, McClelland RS, McCurdy SA. High HIV seroprevalence, rectal STIs and risky sexual behaviour in men who have sex with men in Dar es Salaam and Tanga, Tanzania. BMJ Open. 2014;4(8):e006175.

Schmidt AJ, Marcus U. Self-reported history of sexually transmissible infections (STIs) and STI-related utilization of the German health care system by men who have sex with men: data from a large convenience sample. BMC Infect Dis. 2011;11:132.

Jejeebhoy SJ, Acharya R. Adolescents in Rajasthan 2012: Changing Situation and Needs. New Delhi: Population Council. 2014.

International Institute for Population Sciences (IIPS) and ICF. National Family Health Survey (NFHS-4), 2015-16. Mumbai, India: International Institute for Population Sciences. 2017.

Hiransuthikul A, Prawepray N, Pengpum S, Reankhomfu R, Panpet P, Mahachokchai N et al. Similar Sexually Transmitted Infections Prevalence Despite Lower HIV Prevalence Among Transgender Women Compared with Men Who Have Sex with Men in Thai Community-Based Test and Treat Cohort. In Open Forum Infectious Diseases. US: Oxford University Press. 2017;4(1):S106.

Galvin SR, Cohen MS. The role of sexually transmitted diseases in HIV transmission. Nat Rev Microbiol. 2004;2(1):33-42.

Ho EL, Lukehart SA. Syphilis: using modern approaches to understand an old disease. J Clin Investig. 2011;121(12):4584-92.

Kulkarni V, Parchure R, Darak S. Let's not let the guard down! early indications of syphilis resurgence? Indian J Dermatol Venereol and Leprol. 2019;85(3):246.

Jain A, Mendiratta V, Chander R. Current status of acquired syphilis: A hospital-based 5-year study. Indian J Sex Transm Dis AIDS. 2012;33(1):32.