DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20212555

Rapid development of multiple nonmelanoma skin cancers secondary to ruxolitinib: a case report

Trevor A. Nessel, Jeffrey B. Morris, Tyler Roshak, Bryan D. Sofen

Abstract


Janus kinase (JAK) inhibitors are immunosuppressive medications that function by deactivating the JAK-STAT pathway causing inhibition of cellular growth. Ruxolitinib is a JAK inhibitor that is commonly used to treat disease processes such as myelofibrosis, polycythemia vera and graft versus host disease, with some evidence of benefit with prostate cancer as well. Side effects of ruxolitinib include increased risk of infection, pancytopenia, cardiovascular disease and malignancy relating to the medication’s immunosuppressive effects. Here we reported a 69-year-old male with prostate cancer being treated with ruxolitinib who developed multiple nonmelanoma skin cancers over a 13-month period.


Keywords


Janus kinase inhibitor, Ruxolitinib, Squamous cell carcinoma, Basal cell carcinoma, Nonmelanoma skin cancer, Prostate adenocarcinoma

Full Text:

PDF

References


Vainchenker W, Leroy E, Gilles L, Marty C, Plo I, Constantinescu SN. JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders. F1000Res. 2018;7:82.

Schneider M, Korzeniewski N, Merkle K, Schüler J, Grüllich C, Hadaschik B, et al. The tyrosine kinase inhibitor nilotinib has antineoplastic activity in prostate cancer cells but up-regulates the ERK survival signal-Implications for targeted therapies. Urol Oncol. 2015;33(2):72.

O'Shea JJ, Pesu M, Borie DC, Changelian PS. A new modality for immunosuppression: targeting the JAK/STAT pathway. Nat Rev Drug Discov. 2004;3(7):555-64.

Shodeinde AL, Barton BE. Potential use of STAT3 inhibitors in targeted prostate cancer therapy: Future prospects. Onco Targets Ther. 2012;5:119-25.

Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O'Shea JJ. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases. Nature Rev Drug Discov. 2017;17(1):78.

DePry JL, Reed KB, Cook-Norris RH, Brewer JD. Iatrogenic immunosuppression and cutaneous malignancy. Clin Dermatol. 2011;29(6):602-13.

Harrison CN, Vannucchi AM, Kiladjian J, Al-Ali HK, Gisslinger H, Knoops L, et al. Long-term findings from COMFORT-II, a phase 3 study of ruxolitinib vs best available therapy for myelofibrosis. Leukemia. 2016;30(8):1701-7.