Clinicopathological and dermoscopic correlation of pigmented basal cell carcinoma
Keywords:Basal cell carcinoma, UV radiation, Pigmented variant, Arborizing vessels
AbstractBasal cell carcinoma (BCC), also known as basal cell epithelioma is the most common cutaneous malignancy affecting fair skinned individuals arising from sun exposed skin especially head and neck area. It is a slow growing tumor which rarely metastasizes. UV radiation is the most important predisposing factor. It includes mainly four variants: (a) nodular, (b) pigmented, (c) superficial BCC, (d) sclerosing or morphea form of which most common is nodular variant. Dermoscopy of pigmented BCC shows well focussed arborizing vessels which is the hallmark. The best modality of treatment is surgical excison of tumour, electrodesiccation and curettage, cryosurgery, and Mohs micrographic surgery.
Betti R, Inselvini E, Carducci M, Crosti C. Age and site prevalence of histologic subtypes of Basal cell carcinomas. Int J Dermatol. 1995;34:174-6.
Zuuren EV, Bastiaens MT, Posma AN, Bavinckt JNB. Basal cell carcinoma on the dorsum of the hand: report of 11 cases. J Eur Acad Dermatol Venereol. 2000;14:307-10.
Dai J, Lin K, Huang Y, Lu Y, Chen WQ, Zhang XR, et al. Identification of critically carcinogenesis-related genes in basal cell carcinoma. Onco Targets Ther. 2018;11:6957-67.
Benjamin CL, Ananthaswamy HN. p53 and the pathogenesis of skin cancer. Toxicol Appl Pharmacol. 2007;224(3):241-8.