Bath PUVA versus oral PUVA in the treatment of chronic palmo-plantar psoriasis

Authors

  • Sarker Mahbub Ahmed Shamim Department of Dermatology & Venereology, MH Samorita Hospital & Medical College, Dhaka, Bangladesh Department of Dermatology & Venereology, Dhaka Dermatology Institute, Dhaka, Bangladesh
  • Farhana Rashid Shumi Department of Dermatology & Venereology, Dhaka Dermatology Institute, Dhaka, Bangladesh
  • Rabeya Afroz Shoma Department of Dermatology & Venereology, Dhaka Dermatology Institute, Dhaka, Bangladesh
  • Shumona Sharmin Department of Dermatology & Venereology, Dhaka Dermatology Institute, Dhaka, Bangladesh
  • Sharmin Kabir Department of Dermatology & Venereology, Dhaka Dermatology Institute, Dhaka, Bangladesh
  • Fahima Mumtaz Department of Dermatology & Venereology, Dhaka Dermatology Institute, Dhaka, Bangladesh

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20211426

Keywords:

Psoriasis, Bath PUVA, Oral PUVA, Palmo-plantar, Chronic

Abstract

Background: Psoriasis is a chronic, recurring inflammatory disease of the skin with an unpredictable course and variable prognosis. Palms and/or soles are involved in 10% to 21.1% of all psoriasis cases. Palmo-plantar psoriasis is a therapeutically challenging condition that can significantly impact quality of life. It is frequently resistant to traditional topical therapies, such as potent steroids, calcipotriol and anthralin but show good response to photochemotherapy (PUVA). Aim of the study was to compare the efficacy and safety of bath PUVA versus oral PUVA in patients with chronic palmo-plantar psoriasis.

Methods: This randomized clinical open trial was conducted in the department of dermatology and venereology, BSMMU, Dhaka from 1st September 2007 to 28th February 2008. Patients clinically diagnosed with chronic palmo-plantar psoriasis were selected by simple random sampling. A sample size of 50 patients was taken, 25 for bath PUVA and 25 for oral PUVA group.  Psoriasis area and severity index (PASI) score was used to determine the percentage of reduction of Palmo-plantar psoriasis in both groups. Data were analysed with computer-based program SPSS version.

Results: Reduction of psoriasis at 1st follow-up in bath PUVA and oral PUVA were 29.85±8.95 and 31.93±11.55 respectively. At 2nd follow-up were 85.86±7.33 and 28.48±39.32 respectively. Significantly higher improvement was observed in Bath PUVA group than oral PUVA group, both at 1st and 2nd follow-up (p=0.001).

Conclusions: Bath PUVA was significantly more effective at reducing Palmo-plantar psoriasis than oral PUVA.

Author Biography

Sarker Mahbub Ahmed Shamim, Department of Dermatology & Venereology, MH Samorita Hospital & Medical College, Dhaka, Bangladesh Department of Dermatology & Venereology, Dhaka Dermatology Institute, Dhaka, Bangladesh

Chief consultant

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Published

2021-04-27

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Original Research Articles