Comparative study of efficacy of minoxidil versus minoxidil with platelet rich plasma versus minoxidil with dermaroller in androgenetic alopecia
Keywords:Minoxidil, PRP with minoxidil, Dermaroller with minoxidil, AGA, Hair follicles
Background: Androgenetic alopecia is characterized by progressive hair loss and is recognized as having significant psychological effects on affected patients with a negative impact on QOL. Drug therapies specifically approved by FDA for treating androgenetic alopecia (AGA) are limited to minoxidil and finasteride. There are limited three arm studies comparing treatment modalities in AGA, hence we undertook this study to compare the 3 most common, affordable therapeutic modalities used currently in AGA and their effects.
Methods: This is a prospective comparative parallel group interventional study. 90 subjects recruited into 3 groups, group A treated with minoxidil alone, group B with minoxidil and dermaroller and group C with minoxidil and platelet rich plasma (PRP).
Results: At the end of 5 months 50% patients in group C showed moderate improvement which was found to be superior to the other treatment groups. On the basis of global photographs secondary efficacy analysis was done and all arms were found to have slight improvement. Dermoscopic analysis done at baseline and 5 months showed that group C showed maximum improvement. Pain was the most common side effect noted in group C while pruritus and seborrheic dermatitis was seen more in group A.
Conclusions: Our study showed best results in patients treated with PRP and minoxidil. They have emerged as new non-surgical treatment modalities for AGA, with minimal side effects, good safety profile and patient satisfaction. There are limited three arm studies comparing the efficacy and side effect profile of these 3 modalities in AGA.
Moerman DE. The meaning of baldness and implications for treatment. Clin Dermatol. 1988;6(4):89-92.
Klingman AM, Freeman B. History of baldness: from magic to medicine.Clin Dermatol 1988;6:83–8.
Monselise A, Cohen DE, Wanser R, Shapiro J. What Ages Hair?. Int J Womens Dermatol. 2017;3(1):S52S57.
Wang TL, Zhou C, Shen YW, Wang XY, Ding XL, Tian S, et al. Prevalence of androgenetic alopecia in China: a community‐based study in six cities. Brit J Dermatol. 2010;162(4):843-7.
Tosti A, Duque-Estrada B. Dermoscopy in hair disorders. J Egypt Women Dermatol Soc. 2010;7(1):1–4.
Peterson NSRK. Efficacy of one-day training in low-cost manual preparation of high cellular platelet rich plasma. J Prolotherapy. 2014
Shah KB, Shah AN, Solanki RB, Raval RC. A Comparative Study of Microneedling with Platelet-rich Plasma Plus Topical Minoxidil (5%) and Topical Minoxidil (5%) Alone in Androgenetic Alopecia. Int J Trichology. 2017;9(1):14-8.
Hajheydari Z, Akbari J, Saeedi M, Shokoohi L. Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia. Indian J Dermatol Venereol Leprol. 2009;75:47–51.
Sharma C, Kothiwala R, Meherda A, Ramya BG, Yadav C, Yadav R, Bohara D. Effects of Platelet Rich Plasma in Treatment of Androgenetic Alopecia (AGA): An Interventional Study.
Nyholt, Gillepsie NA, Heath AC, Martin NG.Genetic basis of male pattern baldness. J Invest Dermatol 2005;121:1561-4.
Vaaruni R. A comparative study of treatment modalities in female androgenetic alopecia. Int J Res Medic Sci. 2016;4(4):1229-36.
Shankar DK, Chakravarthi M, Shilpakar R. Male androgenetic alopecia: population-based study in 1,005 subjects. Int J Trichol. 2009;1(2):131.
Dhurat R, Sukesh MS, Avhad G, Dandale A, Pal A, Pund P. A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: A pilot study. Int J Trichol. 2013;5:6-11.