Familial leiomyoma: a case report

Authors

  • Swetha Gutha Department of Dermatology, Vydehi Institute of Medical College, Bangalore, Karnataka, India
  • Shalini Sampath Department of Dermatology, Vydehi Institute of Medical College, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20210585

Keywords:

Familial, Leiomyoma, Leiomyoma cutis

Abstract

Cutaneous leiomyomas are benign tumors that can be exquisitely painful. Comprise three distinct types such as piloleimyoma, angioleiomyoma, and genital leiomyoma. Piloleiomyomas, derived from arrector pili muscle, are solitary or multiple firm papulonodules located mostly on the extremities and trunk; genital leiomyomas, derived from dartoic, vulvar, or mammary smooth muscle, are solitary or papulonodules located on the scrotum, vulva, or nipple; and angioleiomyomas, include solid, cavernous, or venous subtypes, are derived from the tunica media of small arteries and veins and typically present on the extremities. Excisional biopsy is required for diagnosing all cutaneous leiomyomas Histology shows interlacing fibers of spindle cells with moderate amounts of eosinophilic cytoplasm and a blunt-ended, elongated nucleus with perinuclear halos. Surgical excision is curative for cutaneous leiomyomas, with other management options including medical or destructive therapy. A 36-year-old male patient presented with a 13 years history of painful, multiple lesions over the back. Based on the histopathological examination, imaging, and past medical records, a diagnosis of familial leiomyoma was made. His brother had similar disease. The patient was started on tab gabapentin 300mg at night. Patient advised for carbon dioxide laser excision. The present case report has been reported for its interesting clinical presentations and rarity.

Metrics

Metrics Loading ...

References

Holst VA, Junkins-Hopkins JM, Elenitsas R. Cutaneous smooth muscle neoplasms: clinical features, histologic findings, and treatment options. J Am Acad Dermatol. 2002;46:477-490.

Virchow R. Über Makroglossic und patho­ logische Neubildung quergestreifter Muskel­ fasern. Virchows Arch Pathol Anal. 1854;7:126-38.

Koepflcr HW, Krafchuk J, Derbes V. Hereditary multiple leiomyoma of the skin. Am J Hum Genet. 1958;10:48-52.

Sonck CE. Myomatosis cutis miliaris: Report of a case. Acta Dermatol Venereol (Stockh). 1951;31:297-303.

Albrechts S. Froml L. Neoplasias and hyper­ plasias of neural and muscular origin: in Fitz­ patrick TB, Eisen AZ. Wolf K, Frecdberg IN, Austen KF (eds): Dermatology in General Medicine, ed 5. New York. Me Graw-Hill. 1993:1269-279.

Straka BF, Wilson BB. Multiple papules on the leg. Arch Dermatol. 1991;127:1717-720.

Montgomery H, Winkelmann RK. Smooth- muscle tumors of the skin. Arch Dermatol. 1959;79:32-41.

Wachsberg RH, Kyunghee CC, Adekunle A. Two leiomyomas of the liver in an adult with AIDS: CT and MR appearance. J Comput As­ sist Tomogr. 1994;18:156-57.

Tomlinson IP, Alam NA, Rowan AJ. Germline mutations in FH predispose to dominantly inher- ited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet. 2002;30:406-10.

Chuang GS, Martinez-Mir A, Engler DE. Multiple cutaneous and uterine leiomyomata resulting from missense mutations in the fumarate hydratase gene. Clin Exp Dermatol. 2006;31:118-121.

Toro JR, Nickerson ML, Wei MH. Mutations in the fumarate hydratase gene cause hereditary leio- myomatosis and renal cell cancer in families in North America. Am J Hum Genet. 2003;73:95-106.

Alam NA, Barclay E, Rowan AJ. Clinical features of multiple cutaneous and uterine leiomyomatosis: an underdiagnosed tumor syndrome. Arch Dermatol. 2005;141:199-206.

Christenson LJ, Smith K, Arpey CJ. Treatment of mul- tiple cutaneous leiomyomas with CO2 laser ablation. Dermatol Surg. 2000;26:319-322.

Fernandez-Pugnaire MA, Delgado-Florencio V. Familial multiple cutaneous leiomyomas. Dermatology. 1995;191:295-98.

Tiffee JC, Budnick SD. Multiple cutaneous leiomyo- mas. Report of a case. Oral Surg Oral Med Oral Pathol. 1993;76:716-17.

Batchelor RJ, Lyon CC, Highet AS. Successful treat- ment of pain in two patients with cutaneous leiomyo- mata with the oral alpha-1 adrenoceptor antagonist, doxazosin. Br J Dermatol. 2004;150:775-76.

Alam M, Rabinowitz AD, Engler DE. Gabapen- tin treatment of multiple piloleiomyoma-related pain. J Am Acad Dermatol. 2002;46(2)(suppl case reports):S27-S29.

Onder M, Adisen E. A new indication of botulinum toxin: leiomyoma-related pain. J Am Acad Dermatol. 2009;60:325-328.

Downloads

Published

2021-02-22

Issue

Section

Case Reports