DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20205609

Successful treatment of granuloma faciale

Sahar H. Alsharif, Reda H. Saifaldeen, Logain G. Alghanemi

Abstract


Granuloma faciale (GF) is a chronic condition characterized by asymptomatic erythematous plaque with prominent telangiectasia presenting usually over the face. Although the condition is benign, its treatment is often unsatisfactory. Therapeutic modalities that have been tried include topical steroids and topical tacrolimus sometimes enhanced with topical dapsone. Others include intralesional corticosteroids, antimalarials, isoniazid and pulsed-dye laser. We report a case of a 58 years old female with a 1 year history of a solitary slowly progressive plaque over the nose. Diagnosis of GF was made based on the histopathological findings. The patient was started on the combination of topical tacrolimus, intralesional corticosteroids injection and oral doxycycline for 3 months. The patient showed gradual improvement in 3 months without any side effects. This case supports previous papers of successful treatment of GF with topical tacrolimus. There was no recurrence at follow-up 18 months later. It also supports the use of combination therapy especially in resistant cases.


Keywords


Granuloma faciale, Tacrolimus, Doxycycline, Intralesional corticosteroids

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References


Dourmishev L, Ouzounova-Raykova V, Broshtilova V, Miteva L. Granuloma Faciale Effectively Treated with Topical Pimecrolimus. Acta Dermatovenerol Croat. 2014;22(4):305-7.

Shiba K, Moriuchi R, Morita Y, Hamade Y, Miyauchi T, Kikuchi K, Tsuchiya K, Shimizu. Recalcitrant granuloma faciale with 14-year follow-up. Our Dermatol Online. 2017;8(2):183-5.

Claudia Lindhaus, Peter Elsner. Granuloma Faciale Treatment: A Systematic Review. Acta Derm Venereol. 2018;98:14-8.

Radin DA, Mehregan DR. Granuloma Faciale: Distribution of the Lesions and Review of the Literature. Cont Med Educat. 2003;72:213-9.

Jedlickova H, Feit J, Semradova V. Granuloma faciale successfully treated with topical tacrolimus: a case report. Acta Dermatoven APA. 2008;17:34-6.

Tojo G, Fujimura T, Kambayashi Y, Kikuchi K, Aiba S. Successful Treatment of Granuloma Faciale with Topical Tacrolimus: A case report and Immunohistochemical Study. Case Rep Dermatol. 2012;4:158-62.

Dhafiri M, Kaliyadan F. Granuloma Faciale. [online] Statpearls.com. 2019. Available at: https://www.statpearls.com/kb/viewarticle/22401/. Accessed on: 07 January 2020.

Yuan C, Bu W, Chen X, Gu H. A case of granuloma faciale successfully treated with oral prednisone, tranilast and thalidomide. Adv Dermatol Allergol. 2018;XXXV(1):109-12.

Micallef D, Boffa MJ. Complete clearance of resistant granuloma faciale with pulsed dye laser after pre-treatment with mometasone and tacrolimus. J Lasers Med Sci. 2017;8(2):95-7.

Oliveira CC, Ianhez PEC, Marques SA, Marques MEA. Granuloma faciale: clinical, morphological and immunohistochemical aspects in a series of 10 patients. An Bras Dermatol. 2016;91(6):803-7.

Gupta L, Naik H, Kumar NM, Kar HK. Granuloma faciale with extrafacial involvement and response to tacrolimus. J Cutan Aesthet Surg. 2012;5:150-2.