Association between chronic spontaneous urticaria and thyroid autoimmunity: a case control study from a tertiary care centre

Authors

  • Olasseri K. Reena Mariyath Department of Dermatology, Government Medical College, Kozhikode, Kerala, India
  • Manikoth P. Binitha Department of Dermatology, Government Medical College, Kozhikode, Kerala, India
  • Vadakke P. Anilakumari Department of Dermatology, Government Medical College, Kozhikode, Kerala, India
  • George Biju Department of Dermatology, Government Medical College, Kozhikode, Kerala, India
  • Pappinisseri K. Nikhila Department of Dermatology, Government Medical College, Kozhikode, Kerala, India
  • Mann Pradeep Department of Dermatology, Government Medical College, Kozhikode, Kerala, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20170362

Keywords:

Urticaria, Thyroid autoimmunity, Autologous serum skin test

Abstract

Background: The exact etiology of chronic spontaneous urticaria is unknown in the majority of patients. A subset of chronic spontaneous urticaria can be autoimmune and may be associated with thyroid autoimmunity.

Methods: Serum anti thyroid peroxidase (anti-TPO) antibody level and thyroid function tests (TFT) including triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) levels were estimated in 100patients with chronic spontaneous urticaria and 50 controls. Autologous serum skin test (ASST) was done in 84 chronic urticaria patients and 21 patients with high anti-TPO antibody.

Results: High anti-TPO antibodies and abnormal thyroid function were seen in 24 (24%) patients each. High anti-TPO antibody levels were seen in nine (18%) and abnormal TFT in 11 (22%) controls. Abnormal TSH was seen in 22 patients (22%) and 6 (12%) controls. Autologous serum skin test was positive in 53 patients with chronic spontaneous urticaria. It was positive in 16 and negative in five out of 21 patients with high anti-TPO antibody levels.

Conclusions: Though there was a slight increase in abnormal anti-TPO antibody level and thyroid dysfunction in patients with chronic spontaneous urticaria compared to controls, it was not statistically significant.

Author Biographies

Olasseri K. Reena Mariyath, Department of Dermatology, Government Medical College, Kozhikode, Kerala, India

Assistant Professor

Dept of Dermatology & Venereology

Manikoth P. Binitha, Department of Dermatology, Government Medical College, Kozhikode, Kerala, India

Professor & Head

Dept of Dermatology & Venereology

Vadakke P. Anilakumari, Department of Dermatology, Government Medical College, Kozhikode, Kerala, India

Professor & Head

Dept of Nuclear Medicine

George Biju, Department of Dermatology, Government Medical College, Kozhikode, Kerala, India

Assistant Professor

Dept of Community Medicine

Pappinisseri K. Nikhila, Department of Dermatology, Government Medical College, Kozhikode, Kerala, India

Junior Resident

Dept of Dermatology & Venereology

Mann Pradeep, Department of Dermatology, Government Medical College, Kozhikode, Kerala, India

Junior Resident

Dept of Dermatology & Venereology

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Published

2017-02-23

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Original Research Articles