A comparative trial between the therapeutic efficacy of topical 2% sertaconazole cream and 1% terbinafine cream in the treatment of tinea cruris/tinea corporis


  • Sumyuktha J. Department of Dermatology, SRM Medical College and Research Centre, Kattankulathur, Potheri – Kanchipuram, India
  • Murali Narasimhan Department of Dermatology, SRM Medical College and Research Centre, Kattankulathur, Potheri – Kanchipuram, India
  • Parveen Basher Ahamed Department of Dermatology, SRM Medical College and Research Centre, Kattankulathur, Potheri – Kanchipuram, India




Sertaconazole, Terbinafine, Dermatophytosis


Background: Skin infections caused by dermatophyte fungi account for 6% of dermatology consultations at our hospital and 3 to 4% worldwide. A variety of antifungal agents are available for topical use. Terbinafine 1% cream is considered the first line topical medication in the treatment of dermatophytosis. Sertaconazole 2% cream is a relatively new drug having antifungal as well as antiflammatory property. In this prospective study we sought to compare the safety and efficacy of topical 2% Sertaconazole and 1% Terbinafine creams in the treatment of localized tinea cruris and/or tinea corporis.

Methods: In this study, 80 patients were randomized into two groups of 40 each. Group A received 2% Sertaconazole cream while group B received Terbinafine 1% cream topical application twice daily for 4 weeks. Patients were followed up at the end of 2nd and 4th weeks for clinical, mycological (KOH mount and fungal culture) and complete cure (both clinical and mycological).

Results: The mean age of the patients studied was 27.97 years. Complete cure was achieved in 59.5% and 80% in group A and 71.4% and 90.9% in group B at the end of 2nd and 4th weeks respectively. Significant P values were observed if the results were compared within the group, between baseline and 2 weeks, baseline and 4th week and also 2nd and 4th week. Clinically significant side effects were not observed in both the groups.

Conclusions: Although higher cure rates were observed in the Terbinafine treated group, the results were not statistically significant. It can be concluded from our study that Sertaconazole 2% cream is similar in efficacy to Terbinafine 1% cream in the treatment of localized tinea cruris and corporis.


Mohanty JC, Mohanty SK, Sahoo RC, Sahoo AS, Prahraj CH. Incidence of Dermatophytosis in Orissa. Indian J Med Microbiol. 1998;16:78-80.

Singh S, Beena MP. Profile of Dermatophyte infections in Baroda. Indian J Dermatol Venereol Leprosy. 2003;69:281–3.

Sahoo AK, Mahajan R. Management of Tinea Corporis, Tinea Cruris and Tinea Pedis: A Comprehensive review. Indian Dermatol online J. 2016;7:77-86.

El – Gohary M, Van Zurren EJ, Fedorowickz Z, Burgess H, Doney L, Stuart B, et al. Topical antifungal treatments for tinea cruris and tinea corporis. Cochrane database system Rev. 2014;8:CD009992.

Shadomy S, Esoingel Ingroff A, Gebhart RJ: Invitro studies with SF 86-327, a new orally active allylamine derivative. Sabouraudia 1985;23:125-32.

Rhea MP, Theodore R. Topical antifungal agents. In: Wolverton SE. Comprehensive dermatologic drug therapy. 2nd edition. WB Saunders; 2001: 508-9.

Croxtall JD, Plosker GL. Sertaconazole: A review of its use in superficial mycoses in dermatology and gynaecology. Drugs. 2009;69:339-59.

Liebel F, Lyte P, Garay M, Babad J, Southall MD. Anti-inflammatory and anti-itch activity of Sertaconazole nitrate. Arch Dermatol Res. 2006;298:191-9.

Lakshmi V, Bengalorkar GM, Kumar S. Clinical efficacy of topical terbinafine versus luliconazole in the treatment of Tinea corporis / Tinea cruris patients. Br J Pharmacol. 2013;3(4);1001-14.

Budimulja U. Terbinafine 1% cream Vs Bifonazole 1% cream in the treatment of Tinea cruris. In J Dermatol. 1998;37:871-3.

Jerajani HR, Janaki C, Kumar S, Phiske M. Comparative assessment of the efficacy and safety of Sertaconazole 2% cream versus Terbinafine 1% versus Luliconazole 1% cream in patients with Dermatophytoses: A pilot study. Indian J Dermatol. 2013;58:34–8.

Rotta I, Ziegelmann PK, Otuki MF, Riveros BS, Bernardo NL, Correr CJ. Efficacy of topical antifungals in the treatment of Dermatophytosis. A mixed treatment comparison Meta-analysis involving 14 treatments. JAMA Dermatol. 2013;149:341-9.

Sumitha A, Geetha M, Shashikala GH, HS Somashekar, KS chandarn. Efficacy and safety of 1% terbinafine hydrochloride versus 2% Sertaconazole cream in the treatment of tinea corporis. Int J Basic Clin Pharmacol. 2015;4:474–8.

Chaudhary SV, Bisati S, Singh A, Koley S. Efficacy and safety of Terbinafine hydrochloride 1% cream Vs Sertaconazole nitrate 2 % Cruris: A comparative therapeutic trial. Indian J Dermatol. 2013;58:457- 60.

Tamilselvan A, Girisha G, Bhaskar V, Suthakaran R. Comparative evaluation of newer topical antifungal agents in the treatment of superficial fungal infections ( Tinea or Dermatophytic). Int Res J Pharm. 2013;4(6):224–8.






Original Research Articles