Phemphigus vulgaris an autoimmune acantholysis: a case report
DOI:
https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20204572Keywords:
Pemphigus vulgaris, Autoimmune, Blisters, Desmoglein desmosomeAbstract
Pemphigus vulgaris is a rare chronic autoimmune skin disease characterized by a flaccid blister filled with clear fluid that arises on the skin or an erythematous base. The keratinocytes separated by the desmoglein present on the desmosomes which clinically manifests as fluid-filled blisters on the skin. We present pemphigus vulgaris with an unknown cause but good recovery after the management with monoclonal antibodies and corticosteroids in a 30-year-old male patient who came to the hospital with complaints of blisters on the epithelial layers of skin on the face and oral mucosa.
References
Pisanti S, Sharav Y, Kaufman E, Posner LN. Pemphigus Vulgaris; the incidence in jews of different ethnic groups according to age sex and initial lesions. Oral path oral med. Oral Sug. 1974;38(3);382-7.
National center for advancing translational sciences- Genetic and rare disease informational center. https://rarediseases.info.nih.gov/diseases/7355/pemphigus-vulgaris. Last accessed on 20 July 2020.
Sreeshyla HS, Hedge U, Vidya GD. Oral Pemphigus Vulgaris–report of a case with the review on it’s etiopathogenesis. Archives of oral sciences and research.
Rai A, Arora M, Naikmasur V, Sattur A, Malhotra V. Oral Pemphigus Vulgaris: case report. Ethiopian Journal of health sciences. 2015;25(4):637.
Michael H, Carrian S. Pathogenesis, Clinical Manifestation, and diagnosis of Pemphigus. 2013. http//www.uptodate.com/store. Last accessed on 20 July 2020.
Fassmann A, Dvoakova N, Holla IL, Vanuk J, Wotke J. Manifestations of Pemphigus Vulgaris in the orofacial region. Case report script Medica. 2003;76:55-62.
Mahoney MG, Wang Z, Rothenberger K. Explanation for the Clinical and Microscopic localization of lesion in Pemphigus foliaceous and Vulgaris. J Clin Invest. 1999;103:461-8.
Jensen PJ, Barad J, Morioka S. Epidermal Plasminogen activator is abnormal in the cutaneous lesion. J Invert Dermatol. 1988;90:777.
Stanley cell adhesion molecule as a target of autoantibodies in pemphigus and pemphigoid bullous due to defective cell adhesion. Adv Immunol. 1993;53:291-393.
Pradeep AR, Manojkumar ST, Arjun R. Pemphigus Vulgaris associated with significant periodontal findings: A case report. J Calif Dent Association. 2010;38(5):343-60.
