Is laryngeal involvement in pemphigus vulgaris rare? A review

Authors

  • Mohan Bansal Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20160348

Keywords:

Larynx, Pemphigus, Oral ulcer

Abstract

The lesions of pemphigus in the larynx have been reported as case reports. However, the frequency with which it occurs is not known. The purpose of this study was to investigate the incidence of laryngeal involvement in pemphigus vulgaris and to examine the laryngeal lesions and the treatment in detail. The databases searched were PubMed, EMBASE, Cochrane Library and Google scholar. The involvement of larynx in patients with pemphigus vulgaris is common. The most common parts involved are epiglottis and arytenoids. This study indicates that laryngeal symptoms are common in pemphigus vulgaris. Laryngeal findings must be considered at the beginning of diagnosis for the better management and to prevent life threatening complications.

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References

Schneider LC, Schneider AE. Diagnosis of oral ulcers. Mt Sinai J Med. 1998;65(5-6):383-7.

Espana A, Fernandez S, del Olmo J, Marquina M, Pretel M, Ruba D et al. Ear, nose and throat manifestations in pemphigus vulgaris. Br J Dermatol. 2007;156:733-7.

Harman KE, Gratian MJ, Shirlaw PJ, Bhogal BS, Challacombe SJ, Black MM. The transition of pemphigus vulgaris into pemphigus foliaceus: a reflection of changing desmoglein 1 and 3 autoantibody levels in pemphigus vulgaris. Br J Dermatol. 2002;146:684-7.

Tsinias G, Stathas T, Papadas T, Naxakis S, Goumas P. Pemphigus of the oral cavity and larynx: a case report. Otorhinolaryngologia - Head and Neck Surgery. 2013;52:34-6.

Scully C, Challacombe SJ. Pemphigus vulgaris: update on etiopathogenesis, oral manifestations, and management. Crit Rev Oral Biol Med. 2002;13(5):397-408.

Bickle K, Roark TR, Hsu S. Autoimmune bullous dermatoses: a review. Am Fam Physician. 2002;65(9):1861-70.

Mahmoud A, Miziara ID, Costa KC, Santi CG, Maruta CW, Aoki V. Laryngeal involvement in pemphigus vulgaris: a proposed classification. J Laryngol Otol. 2012;126(10):1041-4.

Hale EK, Bystryn JC. Laryngeal and nasal involvement in pemphigus vulgaris. J Am Acad Dermatol. 2001;44(4):609-11.

Vasiliou A, Nikolopoulos TP, Manolopoulos L, Yiotakis J. Laryngeal pemphigus without skin manifestations and review of the literature. Eur Arch Otorhinolaryngol. 2007;264(5):509-12.

Albert MB. Pemphigus Primary in the Larynx. Arch otolaryngol. 1929;10(2):188-9.

Salopek TG, Logsetty S, Tredget EE. Anti-CD20 chimeric monoclonal antibody (rituximab) for the treatment of recalcitrant, life-threatening pemphigus vulgaris with implications in the pathogenesis of the disorder. J Am Acad Dermatol. 2002;47(5):785-8.

Cooper HL, Healy E, Theaker JM, Friedmann PS. Treatment of resistant pemphigus vulgaris with an anti-CD20 monoclonal antibody (Rituximab). Clin Exp Dermatol. 2003;28(4):366-8.

Dupuy A, Viguier M, Bédane C, Cordoliani F, Blaise S, Aucouturier F et al.Treatment of refractory pemphigus vulgaris with rituximab (anti-CD20 monoclonal antibody). Arch Dermatol. 2004;140(1):91-6.

Bansal M. Oral mucosal lesions. Essentials of Ear, Nose and Throat. The Health Sciences Publisher. Jaypee Brothers Medical Publishers (P) Ltd. New Delhi (India); 2016: 262-270.

Bansal M. Oral mucosal lesions. Diseases of Ear, Nose and Throat. Jaypee Brothers Medical Publishers (P) Ltd. New Delhi (India); 2013: 373-386.

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Published

2015-12-25

How to Cite

Bansal, M. (2015). Is laryngeal involvement in pemphigus vulgaris rare? A review. International Journal of Research in Dermatology, 1(1), 3–6. https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20160348

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Section

Review Articles