Prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in vitiligo patients

Authors

  • Jishna P. Department of Dermatology, Government medical college, Kozhikode, Kerala, India
  • M. P. Binitha Department of Dermatology, Government medical college, Kozhikode, Kerala, India
  • Abdul Latheef E. N. Department of Dermatology, Government medical college, Kozhikode, Kerala, India
  • V. P. Anilakumari Department of nuclear medicine, Government medical college, Kozhikode, Kerala, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20170803

Keywords:

Vitiligo, Thyroid dysfunction, Autoimmune thyroid diseases

Abstract

Background: Vitiligo is associated with various autoimmune diseases, including autoimmune thyroid disease. The objectives of the present study was to determine the prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in patients with vitiligo, and to compare the clinical profile of anti-thyroid peroxidase positive and anti-thyroid peroxidase negative patients.

Methods: A cross-sectional comparative study was conducted in 100 patients with vitiligo and 100 controls. After dermatologic and systemic evaluation, serum thyroid hormones and anti-thyroid peroxidase antibody levels were measured in all the subjects.

Results: Thyroid dysfunction was more common in the vitiligo group (27%) than in the controls. Serum thyroid stimulating hormone abnormalities were more common in the vitiligo group (27%) than in the controls (6%). The most common thyroid dysfunction was subclinical hypothyroidism. Anti-thyroid peroxidase antibody positivity was higher in the vitiligo group (36%) when compared to the controls (24%), and the most common type of vitiligo was vitiligo vulgaris (18%) in this group. Thyroid dysfunction and anti-thyroid peroxidase positivity were more common in women (58%) when compared to men (42%). There was a significantly higher prevalence of other autoimmune diseases in the vitiligo group (20%) compared to the controls (6%).

Conclusions: This study shows a significant association between vitiligo and thyroid dysfunction, anti-thyroid peroxidase antibodies and other autoimmune diseases. We recommend that thyroid evaluation and regular follow-up should be done in patients with vitiligo for prompt detection of thyroid dysfunction.

Author Biographies

Jishna P., Department of Dermatology, Government medical college, Kozhikode, Kerala, India

 

junior resident

dept.of dermatology,

govt.medical college,

kozhikde

M. P. Binitha, Department of Dermatology, Government medical college, Kozhikode, Kerala, India

additional professor and head of the department

dept.of dermatology,

govt.medical college,

kozhikde

Abdul Latheef E. N., Department of Dermatology, Government medical college, Kozhikode, Kerala, India

associate professor,

dept. of dermatology,

govt. medical college,

kozhikode

V. P. Anilakumari, Department of nuclear medicine, Government medical college, Kozhikode, Kerala, India

associate professor,

dept. of nuclear medicine,

govt. medical college,

kozhikode

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Published

2017-02-23

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Original Research Articles