Familial diffuse comedones, different entity or variant of familial dyskeratotic comedones: a case report

Authors

  • Nandakishore Thokchom Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • Linda Kongbam Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • Nandita Bhattacharjee Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • Erika Salam Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20203755

Keywords:

Familial dyskeratotic comedones, Comedones, Dyskeratosis

Abstract

Familial dyskeratotic comedones(FDC) is a rare autosomal dominant genodermatosis characterized by numerous comedones with dyskeratosis in histology. We report a case of 43-year-old woman and her 16-year-old daughter presenting with extensive diffuse comedones on the face, trunk and proximal extremities. Mild slate-grey pigmentation of face in the mother was an additional finding. Skin biopsy showed crateriform invagination with parakeratotic lamellae filled with keratinous material in the epidermis but no dyskeratosis or acantholysis. The case resembles FDC as described earlier. However, certain features like presence of hyperpigmentation and minimal hyperkeratotic papules, and absence of dyskeratosis or acantholysis may suggest that diffuse familial comedones exist as a different genodermatosis.

Author Biographies

Nandakishore Thokchom, Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, India

Professor and Head, Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, Pin-795004, India

Linda Kongbam, Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, India

Post Graduate Trainee, Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, Pin-795004, India

Nandita Bhattacharjee, Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, India

Post Graduate Trainee, Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, Pin-795004, India

Erika Salam, Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, India

Post Graduate Trainee, Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, Pin-795004, India

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Published

2020-08-26