A comparative study between micro needling with modified Kligman regimen versus micro needling with tranexamic acid in melasma patients

Authors

  • Anjum M. Momin Department of Dermatology Venereology and Leprosy, SMIMER Medical College, Surat, Gujarat, India
  • Ankita A. Mistry Department of Dermatology Venereology and Leprosy, SMIMER Medical College, Surat, Gujarat, India
  • Jignesh B. Vaishnani Department of Dermatology Venereology and Leprosy, SMIMER Medical College, Surat, Gujarat, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20202658

Keywords:

Melasma, Micro needling, Modified Kligman regimen, Tranexamic acid

Abstract

Background: Melasma is common, acquired disorder of hyperpigmentation, with female predominance and occurrence of facial involvement mostly. Various modalities of treatment are available including topical, oral and procedural therapies.

Methods: Total 46 patients of melasma were studied. They were divided in two groups A and B. Micro needling with derma roller 1.5mm was done once in a month for 3 months. Group A patients received topical Modified Kligman regimen daily at night, while group B patients were advised topical tranexamic acid daily. Topical sunscreen was advised in both group patients. Patients were evaluated clinically and by Modified MASI score, and followed up for 3 more months after completion of treatment.

Results: Female predominance was noted with most common age group being 25-40 years. Epidermal type of melasma was common. Centro-facial type of distribution was found mostly in patients. Significant decrease was noted in modified MASI score (p<0.05) which was more and rapid in group A patients.

Conclusions: Modified Kligman regimen has better efficacy but tranexamic acid is safer with lesser side effects. Inspite of various treatment arms, melasma is still challenging.

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Published

2020-06-23

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Original Research Articles