Eruptive xanthomas: a warning sign of future hyperlipidemia complications


  • Trevor A. Nessel Department of Dermatology, Michigan State University College of Osteopathic Medicine, East Lansing, Michigan
  • Connor C. Kerndt Department of Dermatology, Spectrum Health/Michigan State University College of Human Medicine, Grand Rapids, Michigan
  • John A. Bills Department of Dermatology, Michigan State University College of Osteopathic Medicine, East Lansing, Michigan
  • Lynn Sikorski Department of Dermatology, Beaumont Farmington Hills Hospital, Farmington Hills, Michigan



Eruptive xanthoma, Hypertriglyceridemia, Hypercholesterolemia, Hyperglycemia, Hyperlipidemia


Eruptive xanthomas are localized lipid deposits in the skin or subcutaneous tissue that are associated with both primary and secondary hyperlipidemia. Typical presentation manifests as small yellow papules on the buttocks or extensor surfaces. Xanthomas can be diagnosed clinically with an extensive history and physical examination, however, can be confirmed via biopsy and histological findings. It is essential to identify the underlying cause of the skin lesions and take appropriate measures to prevent future hyperlipidemia-induced consequences. Here we report a 42-year-old female with eruptive xanthomas on her trunk and extremities. Previous visits to the primary care provider and emergency department resulted in diagnoses of viral exanthems. The consulted dermatologist ordered laboratory tests remarkable for extreme hypertriglyceridemia, hypercholesterolemia, and hyperglycemia. Lifestyle modification in conjunction with cholesterol and triglyceride lowering medications led to the resolution of abnormal laboratory findings and remission of eruptive xanthoma lesions.

Author Biography

Lynn Sikorski, Department of Dermatology, Beaumont Farmington Hills Hospital, Farmington Hills, Michigan

Department of Dermatology



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