Autologous serum skin test and skin prick test in patients with chronic urticaria: a cross sectional study


  • Mounika K. Department of Dermatology, M S Ramaiah Medical College, Bangalore, Karnataka, India
  • Shivaswamy K. N. Department of Dermatology, M S Ramaiah Medical College, Bangalore, Karnataka, India



Chronic urticaria, ASST, SPT


Background: Urticaria is an allergic skin disorder characterized by wheals. Though the diagnosis is easy, it is difficult to identify the cause for the episodes. Autologous serum skin test (ASST) and skin prick test (SPT) help in the identification of the cause. The objective of the study was to determine the frequency of ASST and SPT positivity in patients with chronic idiopathic urticaria (CIU).

Methods: Fifty-six patients attending the dermatology OPD with chronic idiopathic urticaria were evaluated and taken up for the study. ASST and SPT were performed on all the patients and the obtained results were documented. Data was analyzed using Chi square test.

Results: Among the 56 patients studied, males (53.57%) outnumbered females and the majority was in the age group 21 to 30 years (33.9%). One third of the study patients gave history of known food allergy and 10.7% gave history of dust allergy. ASST positivity was seen in 30.3% and SPT positivity was seen in 64.3%. Ten of our patients (17.8%) were positive to both ASST and SPT. Amongst the SPT positives 33.3% showed positivity to food allergens, 19.4% showed positivity to aeroallergens and 47.2% showed positivity to both.

Conclusions: ASST and SPT are two reliable tools in identifying the cause for urticaria and this in turn helps in avoidance of possible causes and providing proper treatment.

Author Biography

Mounika K., Department of Dermatology, M S Ramaiah Medical College, Bangalore, Karnataka, India

Associate professor

dept of Dermatology


Konstantinou GN, Asero R, Maurer M, Sabroe RA. EAACI/GA2LEN task force consensus report: Autologous serum skin test in urticaria. Allergy. 2009;64:1256-68.

Donaldson VH, Evans RR. A biochemical abnormality in hereditary angioneurotic edema: absence of serum inhibitor of C1 esterase. Am J Med. 1963;35:37-44.

Kurup VP, Fink JN. The spectrum of immunologic sensitization in latex allergy. Allergy. 2001;56:2-12.

Heinzerlinq L, Mari A, Berqmann KC, Bresciani M, Burbach G, Darsow U, et al. The skin prick test- European standards. Clini and Trans Allergy. 2013;3:3.

George M, Balachandran C, Prabhu S. Chronic idiopathic urticaria: Comparison of clinical features with positive autologous serum skin test. Indian J Dermatol Venereol Leprol. 2008;74:105-8.

Baig SA, Balachandran C, Nayak S. Comparative evaluation of autologous serum skin test and autologous plasma skin test in chronic urticaria. J Pak Assoc Dermatol. 2013;23(4):378-83.

Al-Hamamy HR, Hameed AF, Abdulhadi AS. Autologous serum skin test as a diagnostic aid in chronic idiopathic urticaria. ISRN Dermatol. 2013;2013:291524.

Vikramkumar AG, Kuruvila S, Ganguly S. Autologous serum skin test as an indicator of chronic autoimmune urticariain a tertiary care hospital in South India. Indian Dermatol Online J. 2014;5(6):87-91.

Nath A, Balaji A, Thappa DM. Prick testing in chronic idiopathic urticaria: A report from a tertiary care centre in south India. Internet J Dermatol. 2007;6:2.

Bains P, Dogra A. Skin Prick Test in Patients with Chronic Allergic Skin Disorders. Indian J Dermatol. 2015;60(2):159-64.

Caliskaner Z, Ozturk S, Turan M, Karaayvaz M. Skin test positivity to aeroallergens in patients with chronic urticaria without allergic respiratory disease. J Invest Allergol Clin Immunol. 2004;14(1):50-4.






Original Research Articles