A retrospective study of 100 cases of focal vitiligo treated by autologous, noncultured melanocyte-keratinocyte cell transplantation

Authors

  • E. N. Abdul Latheef Department of Dermatology, Medical College Kozhikode, Kerala, India
  • K. Muhammed Department of Dermatology, Medical College Kozhikode, Kerala, India
  • Najeeba Riyaz Department of Dermatology, Medical College Kozhikode, Kerala, India
  • M. P. Binitha Department of Dermatology, Medical College Kozhikode, Kerala, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20164405

Keywords:

Focal vitiligo, Melanocyte-keratinocyte cell transplantation, Management

Abstract

Background: Vitiligo is a common skin disease affecting 1%-2% of general population. Even though different modalities of treatment available, it remains as a difficult disease to treat. Many cases remain stable after a period of medical therapy without any further response. Surgical techniques are the only hope in such patients. The aim of this study was to evaluate the response of autologous, noncultured melanocyte keratinocyte cell transplantation in patients with stable focal vitiligo.

Methods: A retrospective study of 100 cases focal vitiligo treated by autologous, noncultured melanocyte-keratinocyte cell transplantation. Serial of photographs were taken on each visit. The patents were followed for a period of 5 years. The results were analyzed on a visual analogue scale.

Results: Out of total 100 patients, 44 had excellent (90 to 100%) response, 18 had good (60 to 89%) response, 12 had fair (25 to 59%) response and 26 had poor response (0 to 24%). Age and sex of the patients and size and duration of lesions, did not show significant influence on results of transplantation.

Conclusions: This is a simple, safe, and effective surgical therapy for replenishing the missing melanocytes in resistant cases of vitiligo. Repigmentation lasts long with very good cosmetic acceptability.

Metrics

Metrics Loading ...

Author Biography

E. N. Abdul Latheef, Department of Dermatology, Medical College Kozhikode, Kerala, India

ADDITIONAL PROFESSOR
Department of Dermatology and Venereology, Government
Medical College, Kozhikode, Kerala,

References

Rastogi S, Goyal P, Mangla K, Bhavsar N, Patel H, Rawal RC. Study of transplantation of melanocyte keratinocyte suspension in treatment of vitiligo. Indian J Dermatol. 2006;51(2):142-4.

Mulekar SV. Long-term follow-up study of segmental and focal vitiligo treated by autologous, non-cultured melanocyte-keratinocyte cell trans-plantation. Arch Dermatol. 2004;140:1211-5.

Mulekar SV. Melanocyte-keratinocyte trans-plantation procedure: A few insights. Indian J Dermatol Venereol Leprol. 2016;82:13-5.

Van Geel N, Goh BK, Wallaeys E, Keyser SD, Lambert J. A Review of Non-cultured Epidermal Cellular Grafting in Vitiligo. J Cutan Aesthet Surg. 2011;4:17-22.

Savant SS. Autologous miniature punch skin grafting in stable vitiligo. Indian J Dermatol Venereol Leprol. 1992;58:310-4.

Olsson MJ, Juhlin L. Long-term follow-up of leucoderma patients treated with transplants of autologous cultured melanocytes, ultrathin epidermal sheets and basal cell layer suspension. Br J Dermatol. 2002;147:893-904.

Chen YF, Chang JS, Yang PY, Hung CM, Huang MH, Hu DN. Transplantation of cultured autologous pure melanocytes after laser abrasion for the treatment of segmental vitiligo. J Dermatol. 2000;27:434-9.

Gauthier Y, Benzekri L. Non-cultured epidermal suspension in vitiligo: From laboratory to clinic. Indian J Dermatol Venereol Leprol. 2012;78:59-63.

van Geel N, Wallaeys E, Goh BK, De Mil M, Lambert J. Long term results of non-cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. Br J Dermatol. 2010;163(6):1186-93.

Mysore V, Salim T. Cellular grafts in management of leucoderma. Indian J Dermatol. 2009;54(2):142-9.

Gauthier Y, Surleve-Bazeille J-E. Autologous grafting with noncultured melanocytes:a simplified method for treatment of depigmented lesions. J AmAcad Dermatol. 1992;26:191-4.

Falabella R. Treatment of localized vitiligo by autologous minigrafting. Arch Dermatol. 1988;124:1649-55.

Guerra L, Primavera G, Raskovic D. Erbium: YAG laser and cultured epidermis in the surgical therapy of stable vitiligo. Arch Dermatol. 2003;139:1303-10.

Downloads

Published

2017-02-23

Issue

Section

Original Research Articles