Blistering in a newborn: a rare case report

Authors

  • Jasleen Kaur Department of Dermatology, Venereology and Leprosy, Sri Guru Ramdas Institute of Medical Sciences and Research, Vallah, Amritsar, Punjab, India
  • Jyoti Budhwar Department of Dermatology, Venereology and Leprosy, Sri Guru Ramdas Institute of Medical Sciences and Research, Vallah, Amritsar, Punjab, India
  • Ankush Maheshwary Medical Officer, Khushbir Kalra Memorial Hospital, Amritsar, Punjab, India
  • Karandeep Singh Bhatti Medical Officer, Khushbir Kalra Memorial Hospital, Amritsar, Punjab, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20201596

Keywords:

Epidermolysis bullosa simplex, Trauma, Erosions

Abstract

Epidermolysis bullosa is a heterogeneous group of inherited mechanobullous disorders that present with skin and mucosal fragility, leading to blister formation after minimal trauma. 18 days old female baby presented with fluid-filled blisters of variable sizes over the lower lip, bilateral heels, hands, buttocks, chest, legs and arms, which ruptured spontaneously leaving raw areas. The history and physical examination suggested epidermolysis bullosa simplex and so, skin biopsy was done to confirm the diagnosis. On confirmation, patient’s parents were counselled about the disease and its management.

References

Boeira VLSY, Souza ES, Rocha BO, Oliveira PD, Oliveira MFSP, Rego VRPA, Follador I. Inherited epidermolysis bullosa: clinical and therapeutic aspects. An Bras Dermatol. 2013;88:185-98.

Genetics home reference. Epidermolysis bullosa simplex. Accessed 22 August 2019.

Coulombe PA, Kerns ML, Fuchs E. Epidermolysis Bullosa Simplex: a paradigm for disorders of tissue fragility. J Clin Invest. 2009;119(7):1784-93.

Boanta O, Ognean ML, Olariu E, Kovacs S, Atasie D. Epidermolysis Bullosa-Review. Neonatology. 2012;2(11):44-51.

Fine JD, Eady RA, Bauer EA, Briggaman RA, Tuderman BL, Christiano A et al. Revised classification system for inherited epidermolysis bullosa: report of the Second International Consensus Meeting on diagnosis and classification of epidermolysis bullosa. J Am Acad Dermatol. 2000;42:1051-66.

Marinkovich MP, Bauer EA. Inherited epidermolysis bullosa. In Fitzpatrick’s dermatology in general medicine. 7th ed. New York, NY: McGraw-Hill; 2008:505-16.

Omary MB, Coulombe PA, McLean WH. Intermediate filament proteins and their associated diseases. N Engl J Med. 2004;351:2087-100.

Gu LH, Coulombe PA. Keratin function in skin epithelia: a broadening palette with surprising shades. Curr Opin Cell Biol. 2007;19:13-23.

Epidermolysis bullosa simplex, generalised.

Sarkar R, Bansal S, Garg VK. Epidermolysis bullosa: Where do we stand. Indian J Dermatol Venereol Leprol. 2011;77:431-8.

Zidorio APC, Dutra ES, Leao DOD, Costa IMC. Nutritional aspects of children and adolescents with epidermolysis bullosa: literature review. An Bras Dermatol. 2015;90(2):217-23.

Downloads

Published

2020-04-21

Issue

Section

Case Reports