Association of psoriasis with metabolic disorders and their assessment using epicardial fat thickness, serum lipid profile and homocysteine level

Rajkumar .; Suryakant Ojha; Santhosh Singh; Anil Gupta; Amit Kumar Pandey; Sunil Prajapati

doi:10.18203/issn.2455-4529.IntJResDermatol20194564

Authors

Rajkumar . Department of Dermatology, Venereology and Leprosy, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India
Suryakant Ojha Department of Dermatology, Venereology and Leprosy, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India
Santhosh Singh Department of Dermatology, Venereology and Leprosy, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India
Anil Gupta Department of Dermatology, Venereology and Leprosy, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India
Amit Kumar Pandey Department of Dermatology, Venereology and Leprosy, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India
Sunil Prajapati Department of Dermatology, Venereology and Leprosy, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20194564

Keywords:

Psoriasis, Metabolic disorders, Epicardial fat thickness, Serum lipid profile, Homocysteine level

Abstract

Background: Psoriasis is a chronic immune-mediated inflammatory disease with worldwide prevalence of 2-4%. It is characterized by sharply demarcated erythematous plaque lesions with silvery white scales. A number of literatures have been published concerning that psoriasis is associated with several cardio-metabolic co-morbidities thus increasing the risk of cardiovascular disease and cardiovascular mortality.

Methods: A prospective observational study was done on patients attending Department of DVL, BRD Medical College, Gorakhpur with psoriasis. A total of 150 patients were enrolled for a study period of 1 year from 15^th December 2017 to 31^st December 2018. Statistical analysis was done using Statistical package for the social sciences (SPSS version 16.0).

Results: According to our study mean basal metabolic index in psoriatic patients was 27.4±3.9. The mean cholesterol was 198±38 mg/dl, mean low density lipoproteins 129.5±34 mg/dl, mean triglycerides 140±75 mg/dl which is towards higher side, mean homocysteine being 19.5±1.5 µmol/l while the normal range is 4-15 µmol/l. Epicardial fat thickness on ultrasonograpghy was found to be 7.4±0.5 mm in psoriatic patient.

Conclusions: Psoriasis may elevate the risk of atherosclerosis, particularly cardiovascular disorders. Therefore, from the epidemiological point of view screening of psoriatic patients, particularly those with severe psoriasis should be recommended.

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