DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20173925

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

Girlly Kurian, Krishnan S., Shakthi P.

Abstract


Background: Lichen planus is an autoimmune, inflammatory papulosquamous disease affecting skin and mucous membrane with a possible association with the parameters of metabolic syndrome.

Methods: We carried out a hospital based case control study among patients attending DVL OPD during a period of 1.5 years (January 2015 - May 2016). Study population included 40 cases of LP and 80 age and sex matched controls. Relevant history, clinical examination and blood investigations were done. Diagnosis of MS was made based on IDF criteria.

Results: There was no significant association between metabolic syndrome and lichen planus (p=0.292). Although there was higher prevalence of hypertension (47.5% vs. 27.5%, p=0.029), triglyceride level (25% vs. 10%, p=0.030) and low HDLC levels (65% vs. 45%, p=0.039). We could not establish significant association between FBS and waist circumference with LP.

Conclusions: Though metabolic syndrome was not significantly associated with LP, its components such as hypertension, triglycerides and low HDLC levels were significantly associated with LP as per the study. Therefore patients with LP need to be screened to rule out each of these parameters to avoid later complications.


Keywords


Lichen planus, Metabolic syndrome, Hypertension, Triglyceride

Full Text:

PDF

References


Goldsmith LA, Fitzpatrick TB. Fitzpatrick’s dermatology in general medicine. New York: McGraw-Hill Medical; 2012.

Gorouhi F, Davari P, Fazel N. Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis. Sci World J. 2014;2014:e742826.

Oral Lichen Planus: An Update on Etiology, Pathogenesis, Clinical Presentation, Diagnosis and Management.

Garg VK, Nangia A, Logani K, Sharma RC. Lichen Planus-a Clinico-histopathological. Indian J Dermatol Venereol Leprol. 2000;66(4):193-5.

Rook’s textbook of dermatology. In: Griffiths C, Barker J, Bleiker T, Chalmers R, Creamer D, editors. Ninth edition. Chichester, West Sussex ; Hoboken, NJ: John Wiley & Sons Inc; 2016.

Burns T, Rook GA, editors. Rook’s textbook of dermatology: in four volumes. 8th ed. Oxford: Wiley-Blackwell; 2010.

Arias-Santiago S, Buendía-Eisman A, Aneiros-Fernández J, Girón-Prieto MS, Gutiérrez-Salmerón MT, Mellado VG, et al. Cardiovascular risk factors in patients with lichen planus. Am J Med. 2011;124(6):543–8.

Halimi S, Ferizi M, Gerqari A, Krasniqi N, Ferizi M. GRINSPAN’S SYNDROME – a case report. Case Study Case Rep. 2016;6(3):73–8.

Padhi T, Garima. Metabolic syndrome and skin: Psoriasis and beyond. Indian J Dermatol. 2013;58(4):299.

Padhi T, Garima. Metabolic Syndrome and Skin: Psoriasis and Beyond. Indian J Dermatol. 2013;58(4):299–305.

Zhou S-S, Li D, Zhou Y-M, Cao J-M. The skin function: a factor of anti-metabolic syndrome. Diabetol Metab Syndr. 2012;4:15.

Shen W, Punyanitya M, Chen J, Gallagher D, Albu J, Pi-Sunyer X, et al. Waist Circumference Correlates with Metabolic Syndrome Indicators Better Than Percentage Fat. Obes Silver Spring Md. 2006;14(4):727–36.

Petti S, Rabiei M, De Luca M, Scully C. The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study. Odontology. 2011;99(2):168–78.

Himoto T, Masaki T. Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection. Clin Dev Immunol. 2012;871401.

Das A, Das J, Majumdar G, Bhattacharya N, Neogi D, Saha B. No association between seropositivity for Hepatitis C virus and lichen planus: A case control study. Indian J Dermatol Venereol Leprol. 2006;72(3):198–200.

Lo Muzio L, Santarelli A, Campisi G, Lacaita M, Favia G. Possible link between Hashimoto’s thyroiditis and oral lichen planus: a novel association found. Clin Oral Investig. 2013;17(1):333–6.

Baykal L, Arıca DA, Yaylı S, Örem A, Bahadır S, Altun E, et al. Prevalence of Metabolic Syndrome in Patients with Mucosal Lichen Planus: A Case–Control Study. Am J Clin Dermatol. 2015;16(5):439–45.

Omal P, Jacob V, Prathap A, Thomas N. Prevalence of oral, skin, and oral and skin lesions of lichen planus in patients visiting a dental school in Southern India. Indian J Dermatol. 2012;57(2):107–9.

Mehdipour M, Zenouz AT, Davoodi F, Gholizadeh N, Damghani H, Helli S, et al. Evaluation of the Relationship between Serum Lipid Profile and Oral Lichen Planus. J Dent Res Dent Clin Dent Prospects. 2015;9(4):261–6.

Prasad DS, Kabir Z, Dash AK, Das BC. Prevalence and risk factors for metabolic syndrome in Asian Indians: A community study from urban Eastern India. J Cardiovasc Dis Res. 2012;3(3):204–11.

Parihar A, Sharma S, Bhattacharya SN, Singh UR. A clinicopathological study of cutaneous lichen planus. J Dermatol Dermatol Surg. 2015;19(1):21–6.

Balasubramanyam A, Rao S, Misra R, Sekhar RV, Ballantyne CM. Prevalence of Metabolic Syndrome and Associated Risk Factors in Asian Indians. J Immigr Minor Health. 2008;10(4):313–23.

Atefi N, Majedi M, Peyghambari S, Ghourchian S. Prevalence of diabetes mellitus and impaired fasting blood glucose in patients with Lichen Planus. Med J Islam Repub Iran. 2012;26(1):22–6.

Bagewadi A, Bhoweer AK. Oral Lichen Planus and Its Association with Diabetes Mellitus and Hypertension. J Indian Acad Oral Med Radiol. 2011;23(3):300-3.

Sarkar M, Dayal S, Samanta S, Ghalaut VS, Malik I, Sehgal PK. Serum Leptin and Lipid Profile in Lichen Planus: A Case Control Study. Int J Health Sci Res IJHSR. 2015;5(10):129–35.


Data citation

Nil