Kaposi sarcoma in an immunocompetent patient: a case report

Authors

  • Anjana B. Department of Dermatology, Venerology and Leprology, Jawaharlal Institute of Medical Science, Imphal, Manipur, India
  • Ranjeeta Sapam Department of Dermatology, Venerology and Leprology, Jawaharlal Institute of Medical Science, Imphal, Manipur, India
  • Gurumayum Chitralekha Devi Department of Dermatology, Venerology and Leprology, Jawaharlal Institute of Medical Science, Imphal, Manipur, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20240399

Keywords:

KS, HHV8, Vascular neoplasm, Immunocompetent

Abstract

Kaposi sarcoma (KS) is an uncommon vascular neoplasm associated with human herpes virus 8 (HHV8) infection. Lesions predominantly present at mucocutaneous sites, but may involve other organs. Epidemiological-clinical forms of KS include classic, endemic, AIDS associated and iatrogenic KS. KS is one of the most common AIDS defining malignancy. Lesions evolve from early (patch stage) macule into plaque stage and nodule stage. Diagnosis is made through clinical, histopathological findings and specific immunohistochemical markers for HHV8. Treatment is either by means of destructive procedures and systemic therapy in case of multiorgan involvement. This report is a case of classic KS in a 74-year nondiabetic, non hypertensive female, with no significant surgical, sexual or history of immunosuppression for the occurrence of KS. This case throws light on addressing KS in an immunocompetent patient or a newer variant of KS yet to be researched upon, which can go clinically misdiagnosed due to lack of significant history.

References

Gupta K, Tun A, Gupta A, Berkowitz LB, Anwar R, Liu Y et al. A case of classic Kaposi sarcoma in an immunocompetent human immunodeficiency virus-negative Dominican man. SAGE Open Med Case Rep. 2020;8:2050313X20938249.

Sharma S, Malgotra V, Wani M. Kaposi Sarcoma in an Immunocompetent Patient Treated with Paclitaxel. Cureus. 2023;15(1):e33641.

Reddy NA, Mays SR, Pacha O. Kaposi's Sarcoma in the Immunosuppressed. J Immunotherapy Precision Oncol. 2019;2(3):74-8.

Vangipuram R, Tyring SK. Epidemiology of Kaposi sarcoma: review and description of the nonepidemic variant. Int J Dermatol. 2019;58(5):538-42.

Zeinaty PE, Lebbé C, Delyon J. Endemic Kaposi's Sarcoma. Cancers (Basel). 2023;15(3):872.

Baykal C, Atci T, Buyukbabani N, Kutlay A. The Spectrum of Underlying Causes of Iatrogenic Kaposi's Sarcoma in a Large Series: A Retrospective Study. Indian J Dermatol. 2019;64(5):392-9.

Gonçalves PH, Uldrick TS, Yarchoan R. HIV-associated Kaposi sarcoma and related diseases. AIDS. 2017;31(14):1903-16.

Jakob L, Metzler G, Chen K-M, Garbe C. Non-AIDS Associated Kaposi’s Sarcoma: Clinical Features and Treatment Outcome. PLoS ONE. 2011;6(4):e18397.

Gun S, Baycelebi D, Terzi O, Yıldız L. Histopathological findings in the diagnosis of the stages of kaposi sarcoma; which are more valuable? J Histol Histopathol. 2021;8:4.

Radu O, Pantanowitz L. Kaposi sarcoma. Arch Pathol Lab Med. 2013;137:289-94.

Lebbe C, Garbe C, Stratigos AJ, Harwood C, Peris K, Marmol VD. Diagnosis and treatment of Kaposi's sarcoma: European consensus-based interdisciplinary guideline (EDF/EADO/EORTC). Eur J Cancer. 2019;114:117-27.

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Published

2024-02-23

Issue

Section

Case Reports