Exploring clinical effects and usage patterns of a daily face cleanser enriched with glycolic acid, aloe vera, and vitamin-E for acne management: a post-hoc analysis


  • Pradeep Kumari Asia Institute of Hair Transplant, Pune, Maharashtra, India
  • Deepa K. Bhatt Smt. SCL General Hospital & NHL Municipal Medical College, Ahmedabad, Gujarat, India
  • K. Manoharan Shree Balaji Medical College Hospital, 7 Works Road, Chrompet, Chennai, Tamil Nadu, India
  • Praveen Agarwal Formerly in: L.N.J.P. Hospital, G.B. Pant Hospital, Dr. R.M.L. (Willingdon Hospital) New Delhi, India
  • B. Leelavathy Department of Skin & STD, Bowring Lady Curzon Hospital, Bowring Medical College, Bangalore, Karnataka, India
  • Anurag Arya Fellow member of ASCGI, CSI, Meerut, Uttar Pradesh, India
  • Rathish Nair Medical Strategic Affairs, Torrent Pharmaceuticals Ltd, Ahmedabad, Gujarat, India
  • Krishnaprasad Korukonda Medical Services (India, Row), Torrent Pharmaceuticals Ltd, Ahmedabad, Gujarat, India




Acne, Dermocosmetics, PIH, Skin radiance, Acne spots, Facial cleanser


Background: Face cleansers are recommended as adjuncts to acne therapy to counteract the acne related manifestation like acne spots and post inflammatory hyperpigmentation (PIH). This complementary study was designed to assess the clinical impact and tolerability of glycolic acid, aloe vera and vitamin-E based face cleanser for daily use in acne patients prescribed with clindamycin, tretinoin, adapalene and benzoyl peroxide for management of acne in real-world scenario.

Methods: We conducted a retrospective review at 193 centres, focusing on individuals having acne with oily and mix skin types who used face cleanser twice a day. Total 619 cases (D age: 28.94±7.92 years) of acne were further analysed over a 4-week study period to study improvement in post-inflammatory hyperpigmentation, acne spot reduction and enhance skin radiance and glow using subjective assessment questionnaires.

Results: The face cleanser, when used regularly with standard of care, significantly reduced acne (43.58%), acne spots (44.85%), and PIH (46.06%) with statistical significance (p<0.01). Patients with oily and mix skin type, 337 (54.44%) and 264 (42.65%) rated improvement on acne spots, PIH, radiance, and glow to be good to excellent, respectively. No patients experienced serious adverse events (AEs) or cleanser-related adverse event.

Conclusions: The facial cleanser demonstrated effectiveness and tolerance in treating acne patients who were prescribed with anti-bacterial and anti-inflammatory agents. In 4-week long treatment period, the facial cleanser enhanced skin radiance and also demonstrated its worth as a beneficial inclusion in everyday skincare regimens.



Bhate K, Williams HC. Epidemiology of acne vulgaris. Br Dermatol. 2013;168(3):474-85.

Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease study 2010. Lancet. 2012;380:2163-96.

Tan JK, Bhate K. A global perspective on the epidemiology of acne. Br J Dermatol. 2015;172(1):3-12.

Rocha MA, Bagatin E. Adult-onset acne: prevalence, impact, and management challenges. Clin Cosmet Investig Dermatol. 2018;11:59-69.

Ayer J, Burrows JA. Acne: more than skin deep. Postgraduate Med J. 2006;82(970):500-6.

Tahiliani ST, Saraf VV, Jadhav SP, Poojary PV, Vaidya A, Sawant SV et al. Evaluation of effectiveness and tolerability of a moisturiser as an adjuvant to isotretinoin therapy for acne: a real-world evidence. Int J Res Dermatol. 2023;9(2):67-72.

Tolaymat L, Dearborn H, Zito PM. Adapalene. StatPearls, Treasure Island (FL): StatPearls Publishing. 2023.

Yoham AL, Casadesus D. Tretinoin. StatPearls, Treasure Island (FL): StatPearls Publishing. 2023.

Oon HH, Wong SN, Aw DCW, Cheong WK, Goh CL, Tan HH. Acne Management Guidelines by the Dermatological Society of Singapore. J Clin Aesthet Dermatol. 2019;12(7):34-50.

Fartasch M, Teal J, Menon GK. Mode of action of glycolic acid on human stratum corneum: ultrastructural and functional evaluation of the epidermal barrier. Arch Dermatological Res. 1997;289(7):404-9.

Sharad J. Glycolic acid peel therapy-a current review. Clin Cosmet Investig Dermatol. 2013;6:281-8.

Kaminaka C, Uede M, Matsunaka H, Furukawa F, Yamomoto Y. Clinical evaluation of glycolic acid chemical peeling in patients with acne vulgaris: a randomized, double-blind, placebo-controlled, split-face comparative study. Dermatol Surg. 2014;40:314-22.

Decker A, Graber EM. Over-the-counter acne treatments: a review. J Clin Aesthet Dermatol. 2012;5(5):32-40.

Pinar Ozuguz, Kacar SD, Ekiz O, Takci Z, Balta I, Kalkan G. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutaneous Ocular Toxicol. 2014;33(2):99-102.

Reynolds T, Dweck AC. Aloe vera leaf gel: a review update. J Ethnopharmacol. 1999;68(1-3):3-37.

Yongqiong D, Wang H, Zhou J, Mou Y, Wang G et al. Patients with Acne Vulgaris Have a Distinct Gut Microbiota in Comparison with Healthy Controls. Acta Derm Venereol. 2018;98(8):783-90.

Zhong H, Li X, Zhang W, Shen X, Lu Y, Li H. Efficacy of a New Non-drug Acne Therapy: Aloe Vera Gel Combined With Ultrasound and Soft Mask for the Treatment of Mild to Severe Facial Acne. Front Med (Lausanne). 2021;8:662640.

Dessinioti C, Katsambas A. Antibiotics and Antimicrobial Resistance in Acne: Epidemiological Trends and Clinical Practice Considerations. Yale J Biol Med. 2022;95(4):429-43.

Goh C, Noppakun N, Micali G, Azizan NZ, Boonchai W, Chan Y et al. Meeting the challenges of acne treatment in Asian Patients: a review of the role of dermocosmetics as adjunctive therapy. J Cutan Aesthet Surg. 2016;9(2):85-92.

Khanna N, Kubba R. In World Clinics: Dermatology-Acne. The role of dermocosmetics in modern acne treatment. In: Dermatology: Acne, Jaypee Brothers Medical Publishers Private Limited. 2014;234-51.

Kurokawa I, Kobayashi M, Nomura Y, Abe M, Kerob D, Dreno B. The Role and Benefits of Dermocosmetics in Acne Management in Japan. Dermatol Ther (Heidelb). 2023;13(7):1423-33.

Yousafzai A, Jahan N, Saima S, Javed F, Khan MW, Kanwal R. Extraction of Active Components of Aloe Vera to Treat Acne/pimple in Population of Quetta City, Buitems. ResearchGate. 2012;65-70.

Ayres S, Jr Mihan R. Acne vulgaris: Therapy directed at pathophysiologic defects. Cutis. 1981;28:41-2.






Original Research Articles