Cefditoren pivoxil induced toxic epidermal necrolysis: a case report
DOI:
https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20232550Keywords:
Cefditoren pivoxil, Erythema multiforme, Steroids, Toxic epidermal necrolysisAbstract
Cutaneous adverse drug reactions vary in severity, from mild erythematous skin lesions to life-threatening toxic epidermal necrolysis. Antiepileptics, antipsychotics, antimicrobials, and diuretics are associated with these adverse reactions. We report a case of cefditoren pivoxil-induced toxic epidermal necrolysis in a 46-year-old Indian woman who presented initially with a maculopapular rash that eventually progressed to steroid-refractory toxic epidermal necrolysis. The patient succumbed to her illness on day 33 of the index rash following septic shock.
References
Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T. Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Clin Rev Allergy Immunol. 2018;54(1):147-76.
Phillips EJ, Bouchard CS, Divito SJ. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis-Coordinating Research Priorities to Move the Field Forward. JAMA Dermatol. 2022;158(6):607-8.
Obeid G, Allanore, LV, Wolkenstein P. Toxic Epidermal Necrolysis (TEN) and Stevens-Johnson Syndrome (SJS). Eur Handbook Dermatol Treatments. 2015;971:82.
Alajaji A, Chandra Shekaran J, Mohammed Aldhabbah O, Alhindi HA, Almazyad NS, Aljutayli ZA, et al. Toxic Epidermal Necrolysis (TEN)/Stevens-Johnson Syndrome (SJS) Epidemiology and Mortality Rate at King Fahad Specialist Hospital (KFSH) in Qassim Region of Saudi Arabia: A Retrospective Study. Dermatol Res Pract. 2020;7524726.
Lipovy B, Holoubek J, Hanslianova M, Cvanova M, Klein L, Grossova I, et al. Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications. Microorganisms. 2021;9(1):202.
Sassolas B, Haddad C, Mockenhaupt M, Dunant A, Liss Y, Bork K, et al. ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson syndrome and toxic epidermal necrolysis: Comparison with case-control analysis. Clin Pharmacol Ther. 2010;88:60-8.
Lee EY, Knox C, Phillips EJ. Worldwide Prevalence of Antibiotic-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-analysis. JAMA Dermatol. 2023;159(4):384-92.
Cohen S, Billig A, Ad-El D. Ceftriaxone-induced toxic epidermal necrolysis mimicking burn injury: a case report. J Med Case Rep. 2009;3:9323.
Torres-Navarro I, Abril-Pérez C, Roca-Ginés J, Sánchez-Arráez J, Botella-Estrada R. A case of cefditoren-induced acute generalized exanthematous pustulosis during COVID-19 pandemics. Severe cutaneous adverse reactions are an issue. J Eur Acad Dermatol Venereol. 2020;34(10):e537-9.
Newkirk RE, Fomin DA, Braden MM. Erythema Multiforme Versus Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Subtle Difference in Presentation, Major Difference in Management. Mil Med. 2020;185(9-10):e1847-50.
Iwai S, Sueki H, Watanabe H, Sasaki Y, Suzuki T, Iijima M. Distinguishing between erythema multiforme major and Stevens-Johnson syndrome/toxic epidermal necrolysis immunopathologically. J Dermatol. 2012;39(9):781-6.
Oakley AM, Krishnamurthy K. Stevens Johnson Syndrome. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2023.
Guay DR. Review of cefditoren, an advanced-generation, broad-spectrum oral cephalosporin. Clin Therap. 2001;23(12):1924-3.
Zhang Z, Li S, Zhang Z, Yu K, Duan X, Long L, et al. Clinical Features, Risk Factors, and Prognostic Markers of Drug-Induced Liver Injury in Patients with Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. Indian J Dermatol. 2020;65(4):274-8.
Castrejon JL, Berry N, El-Ghaiesh S, Gerber B, Pichler WJ, Park BK, et al. Stimulation of human T cells with sulfonamides and sulfonamide metabolites. J Allergy Clin Immunol. 2010;125(2):411-8.
Pichler WJ. Immune pathomechanism and classification of drug hypersensitivity. Allergy. 2019;74(8):1457-71.
Chessman D, Kostenko L, Lethborg T, Purcell AW, Williamson NA, Chen Z, et al. Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity. Immunity. 2008;28(6):822-32.
Ye LP, Zhang C, Zhu QX. The Effect of Intravenous Immunoglobulin Combined with Corticosteroid on the Progression of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Meta-Analysis. PloS One. 2016;11(11):e0167120.
