Clobetasol propionate 0.025% cream in the management of steroid responsive dermatoses: an expert opinion

Authors

  • Jayakar Thomas Professor and Head of Dermatology, Chettinad Hospital and Research Institute, Chennai, Tamil Nadu, India
  • Abir Saraswat Consultant Dermatologist Indushree Skin Clinic, Lucknow, Uttar Pradesh, India
  • Sanjeev Aurangabadkar Consultant Dermatologist Dr Aurangabadkar’s Skin and Laser Clinic, Hyderabad, Telangana, India
  • Roheet Rathod Medical Advisor Medical Affairs, Dr. Reddy's Laboratories, Hyderabad, Telangana, India
  • Rahul Rathod Head Innovation Medical Affair’s, Dr. Reddy's Laboratories, Hyderabad, Telangana, India
  • Amey Mane Head Cluster Medical Affairs, Dr. Reddy's Laboratories, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20221204

Keywords:

Topical corticosteroids, Steroid responsive dermatoses, Clobetasol propionate

Abstract

Topical corticosteroids play a key role in managing steroid responsive dermatoses (SRD). Current topical corticosteroid therapies are associated with various disadvantages. The current consensus article aims at providing a collation of evidence-based literature and clinical insights of the experts, regarding the efficacy, safety and usage of clobetasol propionate (CP) 0.025% cream in the management of SRD like plaque psoriasis. Clinical evidences suggest that the novel formulation of CP 0.025% cream has comparable efficacy and a better safety profile vs CP 0.05% cream in the management of plaque psoriasis. According to the doctors' experience, CP 0.025% can be used as first-line treatment for the management of SRD. In children 12-18-year-olds, CP 0.025% may be used cautiously, considering risk-benefit ratio. CP 0.025% may also be used as a maintenance therapy, after disease is brought under control with systemic therapy. Using moisturisers, salicylic acid, calcipotriol or tacrolimus as concomitant therapy with CP 0.025% cream may be beneficial in the management of SRD. In various comorbidities like diabetes and hypertension, CP 0.025% cream may be a better alternative verses CP 0.05% cream. Clinical evidences and experts suggest that for management of SRD, clobetasol propionate 0.025% cream can be recommended as a formulation with comparable efficacy and better safety profile versus CP 0.05% cream.

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Published

2022-04-26

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Review Articles