A clinical study of cutaneous and mucosal manifestations in patients with chronic renal failure on hemodialysis

Mohamed Rafeek M.; Kaliaperumal Karthikeyan

doi:10.18203/issn.2455-4529.IntJResDermatol20170799

Authors

Mohamed Rafeek M. Department of Dermatology, Sri Manakula Vinayagar Medical College & Hospital, Puducherry, India
Kaliaperumal Karthikeyan Department of Dermatology, Sri Manakula Vinayagar Medical College & Hospital, Puducherry, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20170799

Keywords:

Chronic kidney disease, Cutaneous manifestations, Xerosis, Uraemic pruritus

Abstract

Background: Chronic kidney disease is defined as presence of kidney damage, manifested by abnormal albumin excretion or decreased kidney function, quantified by measured or estimated glomerular filtration rate (GFR) that persists for more than 3 months.Chronic kidney disease is major health problem. Chronic kidney failure presents with an array of cutaneous manifestations. The objective of the present study was to determine the pattern of muco-cutaneous manifestations of chronic renal failure on hemodialysis.

Methods: A cross sectional study done in the Dermatology & Nephrology OPD of Sri Manakula Vinayagar Medical College and Hospital from October 2014 to May 2016. About 38 consenting patients who fulfilled the inclusion criteria were chosen for the study. The demographic characteristics were included in the study and the clinical profile of the patient such as hematological investigation and renal function tests were assessed. KOH mount, skin biopsy, Woods lamp, Grams stain and culture & sensitivity were done if needed after getting informed consent from the patients.

Results: The most common cutaneous manifestations in haemodialysis patients were xerosis and uraemic pruritus.

Conclusions: Cutaneous manifestations like uraemic pruritus, Xerosis, Kyrle’s disease, infections, icthyosis & other lesions were seen with Xerosis beimg the most common feature. At least one cutaneous manifestation is found in all CRF patients.

Metrics

Metrics Loading ...

References

Thomas R, Kanso A, Sedor J. Chronic Kidney Disease and its complications. Prim Care. 2008;35(2):329-44.

Sanad EM, Sorour NE, Saudi WM, Elmasry AM. Prevalence of cutaneous manifestations in chronic renal failure patients on regular hemodialysis: a hospital-based study. Egyptian J Dermatol Venerol. 2014;34(1):27.

Pico MR, Lugo-Somolinos A, Sanchez JL, Burgos-Caleron R. Cutaneous alterations in patients with chronic renal failure. Int J Dermatol. 1992;31:860-3.

Sultan M, Mansour H, Wahby I, Houdery A. Cutaneous manifestations in Egyptian patients with chronic renal failure on regular hemodialysis. J Egypt Women Dermatol Soc. 2010;7:49-55.

Bencini, P, Montagnino G, Citterio A, Graziani G, Crosti C, Pontcelli C. Cutaneous abnormalities in uremic patients. Nephron. 1985;40:316-21.

Hajheydari Z, Makhlough A. Cutaneous and mucosal manifestations in patients on maintenance hemodialysis. Iran J Kidney Dis. 2008;2:86-90.

Falodun O, Ogunbiyi A, Salako B, George A. Skin changes in patients with chronic renal failure. Saudi J Kidney Dis Transpl. 2011;22:268-72.

Szepietowski J, Reich A, Schwartz R. Uremic xerosis. Nephrol Dial Transplant. 2004;19:2709-12.

Avermaete A, Altmeyer P, Bacharach-Buhles M. Skin changes in dialysis patients: a review. Nephrol Dial Transplant. 2001;16:2293-6.

Marticorena R, Donnelly S, Ly J. Red blood cell survival in chronic renal failure. Am J Kidney Dis. 2004;44:715-9.

Srinivas C, Mathew A, Udayakumar P, Balasubramanian S, Ramalingam K, Lakshmi C. Cutaneous manifestations in patients with chronic renal failure on hemodialysis. Indian J Dermatol Venereol Leprol. 2006;72(2):119.

Sanai M, Aman S, Nadeem M, Kazmi AH. Dermatologic manifestations in patients of renal disease on hemodialysis. J Pak Assoc Dermatol. 2010;20:163-8.