DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20203539

Contemporary pursuits of vinegar from scullery to dermatology

Mansi Bansal, Umesh Budhiraja, Himanshu Bansal

Abstract


Vinegar is widely available as a food ingredient for flavouring and as a preservative. It is one of the oldest skin remedy known to mankind. However, its status in treatment regimens has declined over the decades. This article is an attempt to highlight its therapeutic armamentarium in dermatology, venereology and leprosy. Acetic acid in vinegar has antibacterial, antifungal and antiviral properties. This review talks about various studies of acetic acid for various indications, such as screening for cervical cancer, healing of chronic wounds, atopic dermatitis, onychomycosis, marine dermatoses, acne vulgaris, warts, in sclerotherapy and many others dermatoses.  Combination therapies and newer indications are also described in this article. Recently, its antiviral action in vitro has been demonstrated against the ongoing coronavirus disease of 2019 (COVID-19) pandemic.


Keywords


Vinegar, Acetic acid, Dermatoses, Vital staining, Black peel, Dermatology

Full Text:

PDF

References


Conner HA, Allgeier RJ. Vinegar: its history and development. Adv Appl Microbiol. 1976;20:81-133.

Sgantzos M, Tsoucalas G, Karamanou M, Giatsiou S, Tsoukalas I, Androutsos G. Hippocrates on pediatric dermatology. Pediatr dermatol. 2015;32:600-3.

Johnston, Carol S. Medicinal uses of vinegar. Complementary and alternative therapies and the aging population. Academic Press. 2009; 433-43.

Budak NH, Aykin E, Seydim AC, Greene AK, Guzel-Seydim ZB. Functional properties of vinegar. J Food Sci. 2014;79:757-64.

Doles W, Wilkerson G, Morrison S, Richmond RG. Glacial acetic acid adverse events: case reports and review of the literature. Hosp Pharm. 2015;50:304-9.

Walter A, Gutknecht J. Monocarboxylic Acid Permeation through Lipid Bilayer-Membranes. J Membrane Biol. 1984;77:255-64.

Halstead FD, Rauf M, Moiemen NS, Bamford A, Wearn CM, Fraise AP et al. The antibacterial activity of acetic acid against biofilm-producing pathogens of relevance to burns patients. PloS one. 2015;10:0136190.

Yagnik D, Serafin V, Shah AJ. Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression. Sci Rep. 2018;8:1-2.

Bjarnsholt T, Alhede M, Jensen PO, Nielsen AK, Johansen HK, Homoe P, et al. Antibiofilm properties of acetic acid. Adv Wound Care. 2014; 1-9.

Cortesia C, Vilcheze C, Bernut A, Contreras W, Gomez K, De Waard J, et al. Acetic acid, the active component of vinegar, is an effective tuberculocidal disinfectant. M Bio. 2014;5:e00013-4.

Mota AC, De Castro RD, De Araújo Oliveira J, De Oliveira Lima E. Antifungal activity of apple cider vinegar on candida species involved in denture stomatitis. J Prosthodont. 2015;24(4):296-302.

Gopal J, Anthonydhason V, Muthu M, Gansukh E, Jung S, Chul S, et al. Authenticating apple cider vinegar’s home remedy claims: antibacterial, antifungal, antiviral properties and cytotoxicity aspect. Natural product research. 2019;33(6):906-10.

Alphin RL, Johnson KJ, Ladman BS, Benson ER. Inactivation of avian infuenza virus using four common chemicals and one detergent. Poult Sci. 2009;88:1181-5.

Pianta L, Vinciguerra A, Bertazzoni G, Morello R, Mangiatordi F, Lund VJ, et al. Acetic acid disinfection as a potential adjunctive therapy for non-severe COVID-19. European Archives of Oto-Rhino-Laryngology. 2020; 1-4.

Pagani I, Ghezzi S, Clementi M, Poli G, Bussi M, Pianta L, et al. Vinegar and Its Active Component Acetic Acid Inhibit SARS-CoV-2 Infection In Vitro and Ex Vivo. BioRxiv. 2020.

Sankaranarayanan R, Wesley R, Somanathan T, Dhakad N, Shyamalakumary B, Amma NS et al. Visual inspection of the uterine cervix after the application of acetic acid in the detection of cervical carcinoma and its precursors. Cancer. 1998;83:2150 6.

Cronjé HS, Parham GP, Cooreman BF, De Beer A, Divall P, Bam RH. A comparison of four screening methods for cervical neoplasia in a developing country. Am J Obstet Gynecol. 2003;188:395 400.

Vinuth DP, Agarwal P, Kale AD, Hallikeramath S, Shukla D. Acetic acid as an adjunct vital stain in diagnosis of tobacco-associated oral lesions: A pilot study. J Oral Maxillofac Pathol. 2015;19:134-8.

Bhalang K, Suesuwan A, Dhanuthai K, Sannikorn P, Luangjarmekorn L, Swasdison S. The application of acetic acid in the detection of oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:371 6.

Gareau DS, Patel YG, Li Y, Aranda I, Halpern AC, Nehal KS, et al. Confocal mosaicing microscopy in skin excisions: a demonstration of rapid surgical pathology. J Microsc. 2009;233(1):149-59.

Nitin S, Raghuveer C. A Review of the Therapeutic Applications of Vinegar. Sch J App Med Sci., 2016;4(11B):3971-76.

O’Meara S, Cullum N, Majid M, Sheldon T. Systematic reviews of wound care management: (3) antimicrobial agents for chronic wounds; (4) diabetic foot ulceration. Health Technol Assess. 2000;4:1 237.

Agrawal KS, Sarda AV, Shrotriya R, Bachhav M, Puri V, Nataraj G. Acetic acid dressings: Finding the Holy Grail for infected wound management. Indian J Plast Surg. 2017;50:273-80.

Molan PC. Re introducing honey in the management of wounds and ulcers-Theory and practice. Ostomy Wound Manag. 2002;48:28 40.

Al-Khalisy M, Ahmed A. Commercial Acetic Acid: A Potential Regenerative Agent for Chronic Cutaneous Wounds? A Quasi-Experimental Study. Glob J Health Sci. 2017;9:178.

Oxford dermatology. Acetic acid vinegar soaks solution. Avaliable at: https://oxforddermato-logy.com.au/wp-content/uploads/2017/09/Wound-Care-Acetic-Acid-Vinegar-Soak.pdf. Accessed on 25 May 2020.

Lim NR, Treister AD, Tesic V, Lee KC, Lio PA. A split body trial comparing dilute bleach vs. dilute apple cider vinegar compresses for atopic dermatitis in Chicago: a pilot study. J Dermat Cosmetol. 2019; 3(1):22-24.

Luu LA, Flowers RH, Kellams AL. Apple cider vinegar soaks(0.5%) as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;00:1-6.

Kumar R, Sachan P, Singh SK, Gupta AK, Mohan L. A prospective observational study on efficacy of black acetic acid combination peel in patients of facial nodulocystic acne. Int J Res Dermatol. 2019;5:673-7.

Madke B, Khopkar U. Pediculosis capitis: An update. Indian J Dermatol Venereol Leprol. 2012;78:429-38.

Moreno-Alsalsua M. Randomized controlled trial on the effect of coconut oil, vinegar plus cooking coconut oil versus 1% permethrin shampoo in the treatment of pediculosis. Ped Infect Dis Soc Phil J. 2016;17(2):4-13.

Sridhar J, Deo R. Marine and other aquatic dermatoses. Indian J Dermatol. 2017;62:66-78.

Goldsmith L A, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K. Fitzpatrick's Dermatology in General Medicine, 8th ed. New York: McGraw-Hill; 2011: 1108.

Kelly S, Liu D, Wang T, Rajpara A, Franano C, Aires D. Vinegar sock soak for tinea pedis or onychomycosis. J Am Acad Dermatol. 2017: 22.

Eertmans F, Doss N, Rossel B, Adriaens E. Daily Application of an Aqueous, Acidifying, Peelable Nail Polish versus Weekly Amorolfine for Topical Onychomycosis Treatment: A Prospective, Randomized, Blinded Trial. Dermatol Ther. 2018;8(3):463-73.

Almirañez JE, Almonte SH, Alvarez AD, Alvero EA, Alviz CA, Alzate ZL, et al. Efficacy of apple cider vinegar as an adjunct to 2% ketoconazole shampoo in the treatment of tinea versicolor: A randomized controlled trial. Available at https://uerm.edu.ph/Forms/research/Vol4%20No1%20January-June%202015.pdf. Accessed on 30 may 2020.

Conzuelo-Quifada AE, Rodriguez-Cuevas SA, Labastida-Almendaro S. Treatment of large lower genital tract condylomata acuminate with local excision plus topical acetic acid. A preliminary study. J Reprod Med. 2003;48:506-8.

Yamamoto Y, Uede K, Yonei N, Kishioka A, Ohtani T, Furukawa F. Effects of alpha-hydroxy acids on the human skin of Japanese subjects: The rationale for chemical peeling. J Dermatol. 2006;33(1):16-22.

Lee SJ, Kim SK, Reza MA, Jang SH, Park SC, Kwon SY. Effect of Chaff Vinegar Liquor on Promotion of Hair Growth in Alopecia Mice Model C57BL/6. Korean J Crop Sci. 2010:426-7.

Cho DS, Ahn HS, Kim SI, Kim YS, Kim SJ, Jeon GS, et al. Sclerotherapy of renal cysts using acetic acid: a comparison with ethanol sclerotherapy. Br J Radiol. 2008: 972, 946-9

Won JH, Kim BM, Kim CH, Park SW, Kim MD. Percutaneous sclerotherapy of lymphangiomas with acetic acid. J Vasc Interv Radiol 2004:15(6):595-600.

Elghblawi E. Black peel in facial dermatoses. J Cosmet Dermatol. 2017;01:1-5.

Mackoff SM. Resistance of skin to acetic acid. J Invest Dermatol. 1950:15(6):397.