Disseminated talaromycosis: an AIDS defining fungal infection

Bijayanti Devi, Sana S., Bharath Meka, Bhuvanesh Raj


Talaromycosis is a systemic mycosis caused by Talaromyces marneffei. It mostly occurs as an opportunistic infection in patients with human immunodeficiency virus (HIV). In India, its endemic in Manipur. We report 3 cases of disseminated talaromycosis with skin eruptions in HIV sero-positive patients from Manipur.


Talaromycosis, Talaromyces marneffi, AIDS, cutaneous penicilliosis

Full Text:



Nittayananta W. Penicilliosis marneffei: Another AIDS defining illness in Southeast Asia. Oral Dis. 1999;5:286-93.

Ustianowski AP, Sieu TP, Day JN. Penicillium marneffei infection in HIV. Curr Opin Infect Dis. 2008;21:31-6.

Vanittanakom N, Cooper CR Jr, Fisher MC, Sirisanthana T. Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects. Clin Microbio Rev. 2006;19:95-110.

Ranjana KH, Priyokumar K, Singh TJ, Gupta ChC, Sharmila L, Singh PN, et al. Disseminated Penicillium marneffei infection among HIV-infected patients in Manipur state, India. J Infect. 2002;45:268-71.

Varghese GM, Pise G, Michael SJ, Jacob M, George R. Disseminated Penicillium marneffei infection in a human immunodeficiency virusinfected individual. J Postgrad Med. 2004;50:235-6.

Maniar JK, Chitale AR, Miskeen A, Shah K, Maniar A. Penicillium marneffei infection: An AIDS-defining illness. Indian J Dermatol Venereol Leprol. 2005;71: 202-4.

Sharma A, Hazarika NK, Barua P, Dey I, Tudu NK. Penicillium marneffei infection in a HIV infected child. Indian J Med Res. 2007;126:580-2.

Devi KR, Singh LR, Rajkumari R, Usharani M, Devi KhS, Singh TB. Penicillium marneffei- an indicator disease of AIDS. Indian J Pathol Microbiol. 2007;50:3:674-6.

George IA, Sudarsanam TD, Pulimood AB, Mathews MS. An acute abdomen: An unusual presentation of disseminated Penicillium marneffei infection. Indian J Med Microbiol. 2008;26:180-2.

Hay RJ, Ashbee HR. Fungal Infections. In: Griffiths C, Barker J, Bleiker T, Chalmers R, Creamer D, editors. Rook's Textbook of Dermatology. 9th ed. UK: Wiley - Blackwell Publication; 2016: 32.90-1.

Supparatpinyo K, Perriens J, Nelson KE, Sirisanthana T. A controlled trial of itraconazole to prevent relapse of Penicillium marneffei infection in patients infected with the human immunodeficiency virus. N Engl J Med. 1998;339:1739-43.

Supparatpinyo K, Nelson KE, Merz WG, Breslin BJ, Cooper CR, Kamwan C, et al. Response to antifungal therapy by human immunodeficiency virus infected patients with disseminated Penicillium marneffei infections and in vitro susceptibilities of isolates from clinical specimens. Antimicrob Agents Chemother. 1993;37(11):2407-11.