Assessment of anti-ageing effects of oral choline-stabilized orthosilicic acid on hair, skin and nails: an open label, non-randomized interventional study


  • B. S. Chandrashekar Department of Dermatology, CUTIS Academy of Cutaneous Sciences, Bengaluru, Karnataka
  • Chaithra Shenoy Department of Dermatology, CUTIS Academy of Cutaneous Sciences, Bengaluru, Karnataka
  • Dharmesh Kumar Kheni Department of Medical Affairs, Sundyota Numandis Group of Companies, Ahmedabad, Gujarat
  • Varun Sureja Department of Medical Affairs, Sundyota Numandis Group of Companies, Ahmedabad, Gujarat



BioSil®, Choline-stabilized orthosilicic acid, Hair, Nail, Skin


Background: Ageing is a continuous process and efforts are being made to reverse or rather slow the process. It is evident through changes in the skin, hair and nails. Due to changes in these, aesthetic appearance is compromised. Choline-stabilized orthosilicic acid (ch-OSA®) has shown results in improving skin, hair and nail health. The aim of the present study was to assess these effects in the Indian population taking oral ch-OSA®.

Methods: Randomly selected 39 participants were assigned to 4 groups to study alopecia, hair quality, skin health and nail health. Ch-OSA®was administered for 5 months. Assessment was made at baseline, 2, 3 and 5 months. After this ch-OSA®was stopped and further assessment was made at 8 months.

Results: There was a significant improvement in terms of all the 11 parameters related to alopecia and hair quality from baseline to 8 months (p<0.001). Most of the participants reported grade-1 skin wrinkling at 5 or 8 months. Skin hydration also improved significantly after the ch-OSA® administration. Greater percentage of participants reported of reduced roughness and dyschromia at the end of the study. Nail parameters were also significantly improved. No side-effect was reported by the participants throughout study.

Conclusions: Oral intake of ch-OSA® showed significant beneficial effects on the health of hair, skin and nails with good tolerability.


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Original Research Articles